A comparative binding study of BIV Tat peptide against its TAR RNA duplex, RNA-DNA heteroduplex and DNA duplex

被引：0
|
作者：
Tok, JBH
Bi, LR
机构：
[1] CUNY York Coll, Dept Chem, Jamaica, NY 11451 USA
[2] CUNY, Grad Ctr, Jamaica, NY 11451 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 01期
关键词：
peptides; fluorescence; nucleic acids; circular dichroism; DNA melt;
D O I：
10.1016/j.bmcl.2004.10.030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Association between RNA and DNA strands to form RNA-DNA heteroduplex is important in many biological processes such as transcription. DNA replication and reverse transcription. Herein, binding affinities of a 17-mer BIV Tat peptide is compared with TAR DNA duplex. TAR RNA-DNA heteroduplex and TAR RNA duplex. It was observed that binding affinities of Tat peptide is comparable against DNA-RNA heteroduplex and RNA duplex, whereas DNA duplex binding is decidedly poor. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：129 / 133
页数：5
相关论文
共 50 条
  • [1] Binding of a cyclic BIV β-Tat peptide with its TAR RNA construct
    Tok, JBH
    Des Jean, RC
    Fenker, J
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (01) : 43 - 46
  • [2] A comparative binding study of modified bovine immunodeficiency virus TAR RNA against its tat peptide
    Tok, JBH
    Bi, LR
    Huang, SY
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (24) : 6101 - 6105
  • [3] Application of RNA-DNA duplex base triplets to antisense drugs
    Yang, J
    Bao, J
    Wang, YL
    JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 2005, 731 (1-3): : 7 - 21
  • [4] Influences of ribonucleotide on a duplex conformation and its thermal stability: Study with the chimeric RNA-DNA strands
    Nakano, S
    Kanzaki, T
    Sugimoto, N
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (04) : 1088 - 1095
  • [5] Binding of the bovine immunodeficiency virus Tat peptide with modified BIV TAR RNA.
    Tok, JBH
    Bi, LR
    Huang, SY
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U163 - U163
  • [6] Binding of the bovine immunodeficiency virus Tat peptide with modified BIV TAR RNA.
    Tok, JBH
    Bi, LR
    Huang, SY
    BIOCHEMISTRY, 2003, 42 (28) : 8612 - 8612
  • [7] Solution conformation of an RNA-DNA hybrid duplex containing a pyrimidine RNA strand and a purine DNA strand
    Hantz, E
    Larue, V
    Ladam, P
    Le Moyec, L
    Gouyette, C
    Dinh, TH
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2001, 28 (04) : 273 - 284
  • [8] Development of cationic oligodiaminogalactoses specifically binding to duplex RNA, but not to duplex DNA
    Torigoe, Hidetaka
    Nakayama, Sumire
    Shiraishi, Tomomi
    Sato, Kazuki
    Hara, Rintaro Iwata
    Wada, Takeshi
    THERMOCHIMICA ACTA, 2024, 738
  • [9] How Tat targets TAR: Structure of the BIV peptide RNA complex
    Greenbaum, NL
    STRUCTURE, 1996, 4 (01) : 5 - 9
  • [10] The Mechanical Properties of RNA-DNA Hybrid Duplex Stretched by Magnetic Tweezers
    Zhang, Chen
    Fu, Hang
    Yang, Yajun
    Zhou, Erchi
    Tan, Zhijie
    You, Huijuan
    Zhang, Xinghua
    BIOPHYSICAL JOURNAL, 2019, 116 (02) : 196 - 204
12345