Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice

被引：19

作者：

Kumakura, Karen ^{[1
]}

Nomura, Hiroshi ^{[1
]}

Toyoda, Takeshi ^{[1
]}

Hashikawa, Koichi ^{[1
]}

Noguchi, Takuya ^{[2
]}

Takeda, Kohsuke ^{[2
]}

Ichijo, Hidenori ^{[2
]}

Tsunoda, Makoto ^{[3
]}

Funatsu, Takashi ^{[3
]}

Ikegami, Daigo ^{[4
]}

Narita, Minoru ^{[4
]}

Suzuki, Tsutomu ^{[4
]}

Matsuki, Norio ^{[1
]}

机构：

[1] Univ Tokyo, Chem Pharmacol Lab, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Lab Cell Signaling, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

[3] Univ Tokyo, Lab Bioanalyt Chem, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

[4] Hoshi Univ, Dept Toxicol, Sch Pharm & Pharmaceut Sci, Tokyo 142, Japan

来源：

NEUROSCIENCE RESEARCH | 2010年 / 66卷 / 03期

关键词：

MAPK; Behavior; Locomotor activity; Rotarod; Motor coordination; Learning; Object recognition memory; Behavioral test battery; LONG-TERM POTENTIATION; EXTRACELLULAR-SUPEROXIDE DISMUTASE; SYNAPTIC PLASTICITY; ASK1; STRESS; PATHWAYS; MEMORY; RAT; DIFFERENTIATION; ACTIVATION;

D O I：

10.1016/j.neures.2009.12.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase family member, which induces apoptosis in various cells through JNK and p38 MAP kinase cascades In addition to apoptosis signaling, a number of recent in vitro studies have suggested that ASK 1 may play roles in neural function However, the behavioral significance of ASK1 has remained unclear Here, we subjected ASK1 (-/-) mice to a battery of behavioral tests and found that they displayed temporary hyperactivity in an open-field test Activities in the familiar field were normal, indicating that the hyperactivity observed was specific to the novel environment. ASK1 (-/-) mice also exhibited impairment of novelty preference 24 h after training and superior performance oil the rotarod test Brain tissue contents of dopamine and 4-dihydroxyphenylacetic acid (DOPAC) were elevated in ASK1 (-/-) mice Our findings thus demonstrate novel behavioral functions of ASK1, including regulation of locomotor activity, novelty preference, and motor coordination with dopaminergic transmission. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society All rights reserved

引用

页码：313 / 320

页数：8

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