Changes in fitness are associated with changes in hippocampal microstructure and hippocampal volume among older adults

被引：71

作者：

Kleemeyer, Maike Margarethe ^{[1
]}

Kuehn, Simone ^{[1
,2
]}

Prindle, John ^{[1
]}

Bodammer, Nils Christian ^{[1
]}

Brechtel, Lars ^{[3
]}

Garthe, Alexander ^{[4
]}

Kempermann, Gerd ^{[4
,5
]}

Schaefer, Sabine ^{[1
,6
]}

Lindenberger, Ulman ^{[1
,7
]}

机构：

[1] Max Planck Inst Human Dev, Lentzeallee 94, D-14195 Berlin, Germany

[2] Univ Clin Hamburg Eppendorf, Clin & Polyclin Psychiat & Psychotherapy, Martinistr 52, D-20246 Hamburg, Germany

[3] Berliner Akad Sportmed eV, SMS Med Inst Berlin, Olympiapk Berlin,Hanns Braun Str,Adlerpl, D-14053 Berlin, Germany

[4] German Ctr Neurodegenerat Dis, Fetscherstr 105, D-01307 Dresden, Germany

[5] Tech Univ Dresden, Ctr Regenerat Therapies, Fetscherstr 105, D-01307 Dresden, Germany

[6] Univ Leipzig, Sportwissensch Fak, Jahnallee 59, D-04109 Leipzig, Germany

[7] European Univ Inst, Via Roccettini 9, I-50014 Fiesole, FI, Italy

来源：

NEUROIMAGE | 2016年 / 131卷

关键词：

Aging; Fitness; Physical exercise; Hippocampal volume; Hippocampal microstructure; Latent difference modeling; GROWTH CURVE MODELS; PHYSICAL-ACTIVITY; INDIVIDUAL-DIFFERENCES; CELL-PROLIFERATION; EXERCISE; BRAIN; NEUROGENESIS; DIFFUSION; PLASTICITY; DYNAMICS;

D O I：

10.1016/j.neuroimage.2015.11.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigates the effects of fitness changes on hippocampal microstructure and hippocampal volume. Fifty-two healthy participants aged 59-74 years with a sedentary lifestyle were randomly assigned to either of two levels of exercise intensity. Training lasted for six months. Physical fitness, hippocampal volumes, and hippocampal microstructure were measured before and after training. Hippocampal microstructure was assessed by mean diffusivity, which inversely reflects tissue density; hence, mean diffusivity is lower for more densely packed tissue. Mean changes in fitness did not differ reliably across intensity levels of training, so data were collapsed across groups. Multivariate modeling of pretest-posttest differences using structural equation modeling (SEM) revealed that individual differences in latent change were reliable for all three constructs. More positive changes in fitness were associated with more positive changes in tissue density (i.e., more negative changes in mean diffusivity), andmore positive changes in tissue density were associated with more positive changes in volume. We conclude that fitness-related changes in hippocampal volume may be brought about by changes in tissue density. The relative contributions of angiogenesis, gliogenesis, and/or neurogenesis to changes in tissue density remain to be identified. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：155 / 161

页数：7