Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe3O4 Magnetic Nanoparticles and Study of Their Antioxidant Activity

被引：9

作者：

Khoobi, Mehdi ^{[1
,2
]}

Ramazani, Ali ^{[3
]}

Hojjati, Zahra ^{[3
]}

Shakeri, Raheleh ^{[4
]}

Khoshneviszadeh, Mehdi ^{[3
,5
]}

Ardestani, Susan Kaboudanian ^{[4
]}

Shafiee, Abbas ^{[3
]}

Foroumadi, Alireza ^{[1
,2
]}

Joo, Sang Woo ^{[6
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran 14176, Iran

[2] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 14176, Iran

[3] Univ Zanjan, Dept Chem, Zanjan, Iran

[4] Univ Tehran, IBB, Tehran, Iran

[5] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz 71345, Iran

[6] Yeungnam Univ, Sch Mech Engn, Kyongsan 712749, South Korea

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2014年 / 189卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

antioxidant; chromenopyrimidinethiones; Fe3O4; nanoparticles; synthesis; cytotoxic activity; SOLVENT-FREE CONDITIONS; ONE-POT SYNTHESIS; SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES; AROMATIC CARBOXYLIC-ACIDS; N-ISOCYANIMINOTRIPHENYLPHOSPHORANE; DIALKYL ACETYLENEDICARBOXYLATES; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; 4-COMPONENT SYNTHESIS; COORDINATION POLYMER;

D O I：

10.1080/10426507.2014.884094

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The aim of the present work was to search for identification of novel reactive oxygen species (ROS) scavengers by testing new fused chromenopyrimidinethiones, which was synthesized using Fe3O4 nanoparticles. The new compounds were also tested for their cytotoxic activity. The obtained results showed that the incorporated pyrimidinethione moiety significantly increase antioxidant activity. In conclusion, the study of the pharmacological properties of the new chromenopyrimidinethiones allowed establishing new structure-activity relationships for splitting antioxidant and cytotoxic activity of these compounds.

引用

页码：1586 / 1595

页数：10

共 54 条

[1] Structural and X-ray powder diffraction studies of nano-structured lead(II) coordination polymer with η2 Pb•••C interactions [J].