Chikungunya virus susceptibility & variation in populations of Aedes aegypti (Diptera: Culicidae) mosquito from India

被引：7
作者：
Gokhale, Mangesh D. [1 ]
Paingankar, Mandar S. [1 ]
Sudeep, Anakathil B. [1 ]
Parashar, Deepti [1 ]
机构：
[1] Microbial Containment Complex ICMR, Natl Inst Virol, Pune 411021, Maharashtra, India
来源：
INDIAN JOURNAL OF MEDICAL RESEARCH | 2015年 / 142卷
关键词：
Chikungunya virus; F statistics; genetic heterogeneity; morphometry analysis; GENETIC-VARIATION; ALBOPICTUS; INFECTION; DENGUE; STRAINS; OUTBREAK;
D O I：
10.4103/0971-5916.176614
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background & objectives: Although having immense clinical relevance, yet only a few studies have been targeted to understand the chikungunya virus (CHIKV) susceptibility and growth in Aedes aegypti populations from India. This study was undertaken to investigate CHIKV susceptibility and growth kinetics in Ae. aegypti along with genetic heterogeneity of Ae. aegypti populations. Methods: Dose dependent CHIKV susceptibility and growth kinetic studies for three CHIKV strains reported from India were carried out in Ae. aegypti mosquito populations. The phenotypic variation and genetic heterogeneity in five Ae. aegypti populations were investigated using multivariate morphometrics and allozyme variation studies. Results: The dissemination and growth kinetics studies of the three CHIKV strains showed no selective advantage for a particular strain of CHIKV in Ae. aegypti. At 100 per cent infection rate, five geographic Ae. aegypti populations showed differences in dissemination to three CHIKV strains. Morphometric studies revealed phenotypic variation in all the studied populations. The allelic frequencies, F statistics, and Nei's genetic identity values showed that genetic differences between the populations were small, but significant. Interpretation & conclusions: The results obtained in this study suggest that genetic background of the vector strongly influences the CHIKV susceptibility in Ae. aegypti.
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页码：33 / 43
页数：11
相关论文
共 38 条
[11]   Large genetic distances among Aedes aegypti populations along the south Pacific coast of Mexico [J].
García-Franco, F ;
Muñoz, MD ;
Lozano-Fuentes, S ;
Fernandez-Salas, I ;
Garcia-Rejon, J ;
Beaty, BJ ;
Black, WC .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 66 (05) :594-598
[12]   Viewpoint: High susceptibility to Chikungunya virus of Aedes aegypti from the French West Indies and French Guiana [J].
Girod, Romain ;
Gaborit, Pascal ;
Marrama, Laurence ;
Etienne, Manuel ;
Ramdini, Cedric ;
Rakotoarivony, Ignace ;
Dollin, Christelle ;
Carinci, Romuald ;
Issaly, Jean ;
Dusfour, Isabelle ;
Gustave, Joel ;
Yp-Tcha, Marie-Michelle ;
Yebakima, Andre ;
Failloux, Anna-Bella ;
Vazeille, Marie .
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2011, 16 (01) :134-139
[13]  
GRAUR D, 1985, EVOLUTION, V39, P190, DOI 10.1111/j.1558-5646.1985.tb04091.x
[14]  
Gubler DJ, 2001, ANN NY ACAD SCI, V951, P13
[15]  
Gurav YK, 2012, INDIAN J MED RES, V136, P886
[16]  
Hedrick P.W., 2000, GENETICS POPULATIONS
[17]   Population genetic structure of the dengue mosquito Aedes aegypti in Venezuela [J].
Herrera, Flor ;
Urdaneta, Ludmel ;
Rivero, Jose ;
Zoghbi, Normig ;
Ruiz, Johanny ;
Carrasquel, Gabriela ;
Antonio Martinez, Jose ;
Pernalete, Martha ;
Villegas, Patricia ;
Montoya, Ana ;
Rubio-Palis, Yasmin ;
Rojas, Elina .
MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2006, 101 (06) :625-633
[18]   Morphometric and allozyme variation in Culex tritaeniorhynchus mosquito populations from India [J].
Kanojia, Phul Chand ;
Paingankar, Mandar S. ;
Patil, Avinash A. ;
Gokhale, Mangesh D. ;
Deobagkar, Dileep N. .
JOURNAL OF INSECT SCIENCE, 2010, 10
[19]   Dynamics of flavivirus infection in mosquitoes [J].
Kramer, LD ;
Ebel, GD .
FLAVIVIRUSES: PATHOGENESIS AND IMMUNITY, 2003, 60 :187-232
[20]   ON A MATCHING PROBLEM ARISING IN GENETICS [J].
LEVENE, H .
ANNALS OF MATHEMATICAL STATISTICS, 1949, 20 (01) :91-94
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