Distinct T cell recognition of naturally processed and cryptic epitopes within the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein

被引：12
|
作者：
Sweenie, Claire H. [1 ]
Mackenzie, Karen J. [1 ]
Rone-Orugboh, Alero [1 ]
Liu, Michael [1 ]
Anderton, Stephen M. [1 ]
机构：
[1] Univ Edinburgh, Inst Immunol & Infect Res, Sch Biol Sci, Edinburgh EH9 3JT, Midlothian, Scotland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 183卷 / 1-2期
基金：
英国医学研究理事会;
关键词：
T cell; autoimmunity; multiple sclerosis; tolerance; antigen processing;
D O I：
10.1016/j.jneuroim.2006.10.018
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have assessed the complexity in T cell recognition of the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein (MOG) in C5713L/6 mice. Immunization with the p35-55 peptide generated two types of T cell, recognizing either a cryptic, or a naturally-processed epitope. Clear differences in the recognition of residues within a core sequence of 40-48 were observed. The majority of the p35-55-reactive repertoire in vivo appeared responsive to the intact autoantigen, supporting the notion of a failure of central tolerance to this region of MOG. Our data also provide a basis for exploring the requirements for antigen processing of MOG. (c) 2006 Elsevier B.V.. All rights reserved.
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页码：7 / 16
页数：10
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