Biological effects of growth hormone on carbohydrate and lipid metabolism

被引：223

作者：

Vijayakumar, Archana ^{[1
]}

Novosyadlyy, Ruslan ^{[1
]}

Wu, YingJie ^{[1
]}

Yakar, Shoshana ^{[1
]}

LeRoith, Derek ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Samuel Bronfman Dept Med, Div Endocrinol Diabet & Bone Dis, New York, NY USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2010年 / 20卷 / 01期

关键词：

GH; Metabolism; Carbohydrate; Lipids; Insulin resistance; GH-DEFICIENT ADULTS; SKELETAL-MUSCLE; FACTOR-I; INSULIN-RESISTANCE; ADIPOSE-TISSUE; TYROSINE PHOSPHORYLATION; PROTEIN-METABOLISM; GENE-EXPRESSION; HEPATIC LIPASE; AMES DWARF;

D O I：

10.1016/j.ghir.2009.09.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review will summarize the metabolic effects of growth hormone (GH) on the adipose tissue, liver, and skeletal muscle with focus on lipid and carbohydrate metabolism. The metabolic effects of GH predominantly involve the stimulation of lipolysis in the adipose tissue resulting in an increased flux of free fatty acids (FFAs) into the circulation. In the muscle and liver, GH stimulates triglyceride (TG) uptake, by enhancing lipoprotein lipase (LPL) expression, and its subsequent storage. The effects of GH on carbohydrate metabolism are more complicated and may be mediated indirectly via the antagonism of insulin action. Furthermore, GH has a net anabolic effect on protein metabolism although the molecular mechanisms of its actions are not completely understood. The major questions that still remain to be answered are (i) What are the molecular mechanisms by which GH regulates substrate metabolism? (ii) Does GH affect Substrate metabolism directly or indirectly via IGF-1 or antagonism of insulin action? (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

共 128 条

[1] Increased p85α is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess [J].

Barbour, LA ;

Rahman, SM ;

Gurevich, I ;

Leitner, JW ;

Fischer, SJ ;

Roper, MD ;

Knotts, TA ;

Vo, Y ;

McCurdy, CE ;

Yakar, S ;

LeRoith, D ;

Kahn, CR ;

Cantley, LC ;

Friedman, JE ;

Draznin, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (45) :37489-37494

[2] HETEROGENEITY OF CIRCULATING GROWTH-HORMONE [J].

BAUMANN, G ;

SHAW, M ;

AMBURN, K ;

JAN, T ;

DAVILA, N ;

MERCADO, M ;

STOLAR, M ;

MACCART, J .

NUCLEAR MEDICINE AND BIOLOGY, 1994, 21 (03) :369-379

[3] Effect of growth hormone on susceptibility to diet-induced obesity [J].

Berryman, Darlene E. ;

List, Edward O. ;

Kohn, Douglas T. ;

Coschigano, Karen T. ;

Seeley, Randy J. ;

Kopchick, John J. .

ENDOCRINOLOGY, 2006, 147 (06) :2801-2808

[4] Comparing adiposity profiles in three mouse models with altered GH signaling [J].

Berryman, DE ;

List, EO ;

Coschigano, KT ;

Behar, K ;

Kim, JK ;

Kopchick, JJ .

GROWTH HORMONE & IGF RESEARCH, 2004, 14 (04) :309-318

[5] Transgenic Mice Overexpressing Growth Hormone (GH) Have Reduced or Increased Cardiac Apoptosis through Activation of Multiple GH-Dependent or -Independent Cell Death Pathways [J].

Bogazzi, Fausto ;

Russo, Dania ;

Raggi, Francesco ;

Ultimieri, Federica ;

Urbani, Claudio ;

Gasperi, Maurizio ;

Bartalena, Luigi ;

Martino, Enio .

ENDOCRINOLOGY, 2008, 149 (11) :5758-5769

[6] Metformin restores responses to insulin but not to growth hormone in Sprague-Dawley rats [J].

Borst, SE ;

Snellen, HG ;

Ross, H ;

Scarpace, PJ ;

Kim, YW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 291 (03) :722-726

[7] Low utilization of circulating glucose after food withdrawal in Snell dwarf mice [J].

Brooks, Natasha L. ;

Trent, Chad M. ;

Raetzsch, Carl F. ;

Flurkey, Kevin ;

Boysen, Gunnar ;

Perfetti, Michael T. ;

Jeong, Yo-Chan ;

Klebanov, Simon ;

Patel, Kajal B. ;

Khodush, Valerie R. ;

Kupper, Lawrence L. ;

Carling, David ;

Swenberg, James A. ;

Harrison, David E. ;

Combs, Terry P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (48) :35069-35077

[8] Adipocyte insensitivity to insulin in growth hormone-transgenic mice [J].

Chen, XL ;

Lee, K ;

Hartzell, DL ;

Dean, RG ;

Hausman, GJ ;

McGraw, RA ;

Della-Fera, MA ;

Baile, CA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 283 (04) :933-937

[9] Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: Relationship with caloric restriction [J].

Chiba, Takuya ;

Yamaza, Haruyoshi ;

Komatsu, Toshimitsu ;

Nakayama, Masahiko ;

Fujita, Satoshi ;

Hayashi, Hiroko ;

Higami, Yoshikazu ;

Shimokawa, Isao .

EXPERIMENTAL GERONTOLOGY, 2008, 43 (06) :595-600

[10] The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats [J].

Cho, Yoshitake ;

Ariga, Miyako ;

Uchijima, Yasunobu ;

Kimura, Kumi ;

Rho, Jeung-Yon ;

Furuhata, Yasufumi ;

Hakuno, Fumihiko ;

Yamanouchi, Keitaro ;

Nishihara, Masugi ;

Takahashi, Shin-Ichiro .

ENDOCRINOLOGY, 2006, 147 (11) :5374-5384

← 1 2 3 4 5 6 7 8 9 10 →