Postnatal decrease in substantia nigra echogenicity - Implications for the pathogenesis of Parkinson's disease

被引：28

作者：

Iova, A

Garmashov, A

Androuchtchenko, N

Kehrer, M

Berg, D

Becker, G

Garmashov, Y

机构：

[1] Inst Med Genet, D-72076 Tubingen, Germany

[2] St Petersburg Med Acad Postgrad Educ, Dept Child Neurol & Neurosurg, St Petersburg, Russia

[3] Univ Childrens Hosp, Dept Child Neurol, Tubingen, Germany

[4] Univ Childrens Hosp, Dept Neonatol, Tubingen, Germany

[5] Univ Saarland, Dept Neurol, D-6650 Homburg, Germany

来源：

JOURNAL OF NEUROLOGY | 2004年 / 251卷 / 12期

关键词：

Parkinson's disease; iron metabolism; transcranial ultrasound;

D O I：

10.1007/s00415-004-0556-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Increased echogenicity of the substantia nigra (SN) on transcranial ultrasonography (TCS) is a typical sign in Parkinson's disease (PD). Detected in healthy adults it is assumed to represent a risk factor for nigral injury. We studied at which time point of brain maturation increased signal intensity may occur by performing TCS scans in 109 newborns and children aged 0-192 months. While newborns regularly exhibit SN hyperechogenicity, this echofeature decreases substantially during the first years of life. As SN echogenicity is related to the tissue iron content in adults our findings suggest a failure in SN iron metabolism in some children with increased echogenicity during development which can be disclosed by TCS.

引用

页码：1451 / 1454

页数：4

共 17 条

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