A ratiometric near-infrared fluorescent probe with a large emission peak shift for sensing and imaging hypochlorous acid

被引：50

作者：

He, Meng ^{[1
,2
]}

Ye, Miantai ^{[3
]}

Wang, Zhengguo ^{[4
]}

Liu, Pan ^{[1
,2
]}

Li, Huiyue ^{[1
,2
]}

Lu, Chunfeng ^{[1
,2
]}

Wang, Yanying ^{[1
,2
]}

Liang, Tao ^{[1
,2
]}

Li, Haiyan ^{[1
,2
]}

Li, Chunya ^{[1
,2
]}

机构：

[1] South Ctrl Univ Nationalities, Coll Chem & Mat Sci, Key Lab Catalysis & Energy Mat Chem, Minist Educ, Wuhan 430074, Peoples R China

[2] South Ctrl Univ Nationalities, Coll Chem & Mat Sci, Key Lab Analyt Chem State Ethn Affairs Commiss, Wuhan 430074, Peoples R China

[3] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[4] Hezhou Univ, Inst Food Sci & Engn Technol, Hezhou 542899, Guangxi, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2021年 / 343卷

基金：

中国国家自然科学基金;

关键词：

Near-infrared; Raiometric; Fluorescent imaging; Hypochlorous acid; Diabetic wound healing; OXIDATIVE STRESS; MITOCHONDRIA; MECHANISMS; VISCOSITY; DESIGN;

D O I：

10.1016/j.snb.2021.130063

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Diabetes, a kind of metabolic disease with characteristics of chronic hyperglycemia, can trigger a series of complications. Among them, wound healing prolonging is one of the manifestations of complications. Hypochlorous acid (HOCl) is a ubiquitous reactive oxygen species (ROS) that plays a vital role in inflammatory response and has been considered as a biomarker for monitoring a wound healing process. Herein, a ratiometric near-infrared (NIR) fluorescent probe, CX-MTC, was synthesized and applied for monitoring HOCl. CX-MTC possesses a simple structure and can be easy synthesized. The probe shows itself emission at 525 nm, a new emission at 665 nm is observed after the reaction with HOCl with a large emission shift of 140 nm. CX-MTC provides excellent selectivity and high sensitivity towards HOCl with 63-fold fluorescence intensity ratio enhancement. The probe can be used for monitoring HOCl in cells. Moreover, CX-MTC was successfully used for imaging HOCl in OGD/R cell model. It is also the first fluorescent probe for HOCl detection in diabetic wound healing process, which will be a potentially useful strategy for clinical assay.

引用

页数：8

共 43 条

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