Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients

被引：1
作者：
Ohara, Emi [1 ]
Tokuyama, Hirotake [1 ,2 ]
Kitamoto, Takumi [1 ,3 ]
Kitahara, Aya [3 ]
Hayashi, Aiko [1 ,3 ]
Hayashi, Hideki [4 ]
Takemoto, Minoru [1 ,5 ]
Yokote, Koutaro [1 ,3 ]
机构：
[1] Chiba Univ, Grad Sch Med, Dept Clin Cell Biol & Med, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan
[2] Yu Karigaoka Tokuyama Clin, Sakura, Chiba 2850850, Japan
[3] Chiba Univ Hosp, Div Diabet Metab & Endocrinol, Dept Med, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan
[4] Chiba Univ, Grad Sch Med, Dept Frontier Surg, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan
[5] Int Univ Hlth & Welf, Dept Diabet Metab & Endocrinol, Sch Med, 4-3 Kozunomori, Narita, Chiba 2868686, Japan
来源：
OBESITY SURGERY | 2017年 / 27卷 / 08期
关键词：
Growth hormone; Laparoscopic sleeve gastrectomy; GHRP-2; AGHD; GH DEFICIENCY; MASS; MEN;
D O I：
10.1007/s11695-017-2769-4
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Because growth hormone (GH) secretion is reportedly decreased in obese patients, we examined not only the factors associated with the decreased GH secretion but also GH response to the GH-releasing peptide (GHRP)-2-load test before and after laparoscopic gastrectomy (LSG). The study comprised 28 individuals aged 19-65 years [mean body mass index (BMI), 39.4 +/- 9.4 kg/m(2)]. In the univariate analysis, GH secretion peaks correlated negatively with BMI (r = -0.59, p = 0.001), visceral adipose tissue (r = -0.47, p = 0.005), and subcutaneous adipose tissue (r = -0.40, p = 0.04). In the two obese patients, the response to the GHRP-2-load test markedly improved by weight loss 12 months after LSG. In conclusion, GH secretion was decreased in obese patients and improved by LSG.
引用
收藏
页码：2214 / 2217
页数：4
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