Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients

被引:1
作者
Ohara, Emi [1 ]
Tokuyama, Hirotake [1 ,2 ]
Kitamoto, Takumi [1 ,3 ]
Kitahara, Aya [3 ]
Hayashi, Aiko [1 ,3 ]
Hayashi, Hideki [4 ]
Takemoto, Minoru [1 ,5 ]
Yokote, Koutaro [1 ,3 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Clin Cell Biol & Med, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan
[2] Yu Karigaoka Tokuyama Clin, Sakura, Chiba 2850850, Japan
[3] Chiba Univ Hosp, Div Diabet Metab & Endocrinol, Dept Med, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan
[4] Chiba Univ, Grad Sch Med, Dept Frontier Surg, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan
[5] Int Univ Hlth & Welf, Dept Diabet Metab & Endocrinol, Sch Med, 4-3 Kozunomori, Narita, Chiba 2868686, Japan
关键词
Growth hormone; Laparoscopic sleeve gastrectomy; GHRP-2; AGHD; GH DEFICIENCY; MASS; MEN;
D O I
10.1007/s11695-017-2769-4
中图分类号
R61 [外科手术学];
学科分类号
摘要
Because growth hormone (GH) secretion is reportedly decreased in obese patients, we examined not only the factors associated with the decreased GH secretion but also GH response to the GH-releasing peptide (GHRP)-2-load test before and after laparoscopic gastrectomy (LSG). The study comprised 28 individuals aged 19-65 years [mean body mass index (BMI), 39.4 +/- 9.4 kg/m(2)]. In the univariate analysis, GH secretion peaks correlated negatively with BMI (r = -0.59, p = 0.001), visceral adipose tissue (r = -0.47, p = 0.005), and subcutaneous adipose tissue (r = -0.40, p = 0.04). In the two obese patients, the response to the GHRP-2-load test markedly improved by weight loss 12 months after LSG. In conclusion, GH secretion was decreased in obese patients and improved by LSG.
引用
收藏
页码:2214 / 2217
页数:4
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