An efficient one-pot expeditious synthesis of 3-phenyl-1-(6-phenyl-7H-[1,2,4] triazolo[3,4-b] [1,3,4] thiadiazin-3-yl)-1H-pyrazol-5-amines via multicomponent approach

被引：9

作者：

Sujatha, Kodam ^{[1
]}

Deshpande, Ravindra Pramod ^{[2
]}

Kesharwani, Rajesh Kumar ^{[3
]}

Babu, Phanithi Prakash ^{[2
]}

Vedula, Rajeswar Rao ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Chem, Warangal 506004, Telangana, India

[2] Univ Hyderabad, Dept Biotechnol & Bioinformat, Sch Life Sci, Hyderabad, India

[3] Nims Univ Rajasthan, Dept Adv Sci & Technol, NIET, Jaipur, Rajasthan, India

来源：

SYNTHETIC COMMUNICATIONS | 2019年 / 49卷 / 01期

关键词：

Multicomponent reaction; phenacyl bromide; 3-(2-bromoacetyl)-2H-chromen-2-one; triazolothiadiazine; TRIAZOLOTHIADIAZINE DERIVATIVES; PYRAZOLE; THIAZOLE; ANALOGS; DESIGN;

D O I：

10.1080/00397911.2018.1537398

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3-phenyl-1-(6-phenyl-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-1H-pyrazol-5-amines was accomplished by a simple, atom-economical, and multicomponent approach. Reaction of 4-amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol with various phenacyl bromides and benzoylacetonitriles in ethanol and catalytic amount of acetic acid afforded the titled compounds. The structures of newly synthesized compounds were confirmed by their analytical and spectral (IR, H-1-NMR, C-13-NMR, and Mass) data.

引用

页码：49 / 55

页数：7

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