Two new peroxy fatty acids with antibacterial activity from Ophioglossum thermale Kom

被引：15

作者：

Dong, Jian-Wei ^{[1
]}

Cai, Le ^{[1
]}

Li, Xue-Jiao ^{[1
]}

Peng, Li ^{[1
]}

Xing, Yun ^{[1
]}

Mei, Rui-Feng ^{[1
]}

Wang, Jia-Peng ^{[1
]}

Ding, Zhong-Tao ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China

来源：

FITOTERAPIA | 2016年 / 109卷

关键词：

Ophioglossum thermale Kom; Thermalic acid A; Thermalic acid B; Peroxy fatty acid; Antibacterial activity; ANTIOXIDANT; HOMOFLAVONOIDS;

D O I：

10.1016/j.fitote.2015.12.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new peroxy fatty adds, thermalic adds A (1) and B (2), together with eight known compounds, (3 beta)-methyl-3-hydroxy-urs-11-en-28 oate (3), luteolin (4), quercetin (5), 3-methoxyquercetin (6), ophioglonol (7), ophioglonol 4'-O-alpha-D-glucopyranoside (8), pedunculosumoside B (9), syringol (10), were isolated from the herba of Ophioglossum thermale Mom. The structures of 1 and 2 were identified by HRESIMS, EIMS, 1D and 2D NMR, and electronic circular dichroism (ECD) spectra. Both two acids exhibited potential antibacterial activities against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. This is the first report of peroxy fatty acids isolated from herbaceous plants of Ophioglossaceae. (C) 2016 Elsevier B.V. All rights reserved.

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页码：212 / 216

页数：5

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