Angiotensin (Ang) II is believed to be a potential pro-inflammatory factor. The capability of Ang II to stimulate C-reactive protein (CRP) production has recently been described. Genetic polymorphisms of renin angiotensin system (RAS) components have been described to be associated with the development of coronary artery disease (CAD). This study investigated the association between six different genetic polymorphisms of RAS and serum CRP levels in a sample of CAD patients. Genotyping of RAS genes polymorphisms in 176 patients with documented CAD was performed by a modified polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Measurement of high-sensitivity (hs)-CRP was performed using standard immunoturbidimetric methods. Results show no significant differences in serum CRP regarding different variants of the six polymorphisms studied (p = 0.41, 0.24, 0.25, 0.19, 0.29, and 0.05 for Ang-converting enzyme (ACE) insertion/deletion (I/D), A-240T and A2350G, angiotensinogen M235T, AT1 receptor A1166C, and AT2 receptor C3123A polymorphisms, respectively). In conclusion, genetic polymorphisms of RAS are not associated with increased serum CRP in CAD. Compensation of an increased activity of ACE through counter-regulation and the secretion of CRP under the influence of Ang II in the vessel being local could explain the lack of association between the studied polymorphisms and CRP levels in CAD patients.
机构:
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Columbia Univ, Newyork Presbyterian Hosp, Irving Med Ctr, New York, NY USACardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Chen, Shmuel
Redfors, Bjorn
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Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Columbia Univ, Newyork Presbyterian Hosp, Irving Med Ctr, New York, NY USA
Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, SwedenCardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Redfors, Bjorn
Serruys, Patrick W.
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Natl Univ Ireland Galway NUIG, Dept Cardiol, Galway, Ireland
Imperial Coll London, Dept Cardiol, London, EnglandCardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Serruys, Patrick W.
Kappetein, Arie Pieter
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Erasmus MC, Thoraxctr, Rotterdam, NetherlandsCardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Kappetein, Arie Pieter
Crowley, Aaron
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Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY USACardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Crowley, Aaron
Ben-Yehuda, Ori
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Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Columbia Univ, Newyork Presbyterian Hosp, Irving Med Ctr, New York, NY USA
Univ Calif San Diego, Div Cardiol, San Diego, CA 92103 USACardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Ben-Yehuda, Ori
Srdanovic, Iva
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Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY USACardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Srdanovic, Iva
Lembo, Nicholas J.
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Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Columbia Univ, Newyork Presbyterian Hosp, Irving Med Ctr, New York, NY USACardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Lembo, Nicholas J.
Brown, W. Morris, III
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Piedmont Heart Inst, Atlanta, GA USACardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Brown, W. Morris, III
Sabik, Joseph F., III
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UH Cleveland Med Ctr, Dept Surg, Cleveland, OH USACardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Sabik, Joseph F., III
Stone, Gregg W.
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Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA
Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USACardiovasc Res Fdn, Clin Trials Ctr, New York, NY USA