Cancer Nucleus: Morphology and Beyond

被引：89
作者：
Dey, Pranab [1 ]
机构：
[1] Postgrad Inst Med Educ & Res, Dept Cytol, Chandigarh 160012, India
来源：
DIAGNOSTIC CYTOPATHOLOGY | 2010年 / 38卷 / 05期
关键词：
nucleus; cancer; morphology; POLYMERASE-I TRANSCRIPTION; NEEDLE-ASPIRATION-CYTOLOGY; BREAST EPITHELIAL-CELLS; CHROMATIN TEXTURE; RETINOBLASTOMA PROTEIN; HISTONE DEACETYLASE; MATRIX PROTEINS; IMAGE MORPHOMETRY; PERINUCLEOLAR COMPARTMENT; BIOLOGICAL-CONTROL;
D O I：
10.1002/dc.21234
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
There are many significant morphological alterations of a nucleus of cancer cell that are detectable by light microscopy on routine staining. These changes are often associated with deranged cellular functions of cancer cell. It is difficult to understand the exact relationship between nuclear morphology and alteration of nuclear structural organization in cancer. Herein, the salient visual and subvisual morphological changes of cancer nuclei and their possible etiology and significance have been reviewed. Diagn. Cytopathol. 2010;38:382-390. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：382 / 390
页数：9
相关论文
共 107 条
[1]   Nuclear fragments and holes in grading of breast cancer aspirates [J].
Abodief, W. T. ;
Dey, P. ;
Al-Hattab, O. ;
Al-Jassar, A. .
CYTOPATHOLOGY, 2006, 17 (04) :215-216
[2]   Histone acetylation and cancer [J].
Archer, SY ;
Hodin, RA .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (02) :171-174
[3]   THE HISTONE FOLD - A UBIQUITOUS ARCHITECTURAL MOTIF UTILIZED IN DNA COMPACTION AND PROTEIN DIMERIZATION [J].
ARENTS, G ;
MOUDRIANAKIS, EN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :11170-11174
[4]   COACTIVATOR AND PROMOTER-SELECTIVE PROPERTIES OF RNA-POLYMERASE-I TAFS [J].
BECKMANN, H ;
CHEN, JL ;
OBRIEN, T ;
TJIAN, R .
SCIENCE, 1995, 270 (5241) :1506-1509
[5]  
BIBBO M, 1981, ACTA CYTOL, V25, P23
[6]   The mutator phenotype theory of carcinogenesis and the complex histopathology of tumours: support for the theory from the independent occurrence of nuclear abnormality, loss of specialisation and invasiveness among occasional neoplastic lesions [J].
Bignold, LP .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (05) :883-891
[7]   The multifunctional nucleolus [J].
Boisvert, Francois-Michel ;
van Koningsbruggen, Silvana ;
Navascues, Joaquin ;
Lamond, Angus I. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (07) :574-585
[8]   Role of immunocytochemistry and DNA flow cytometry in the fine-needle aspiration diagnosis of malignant small round-cell tumors [J].
Brahmi, U ;
Rajwanshi, A ;
Joshi, K ;
Ganguly, NK ;
Vohra, H ;
Gupta, SK ;
Dey, P .
DIAGNOSTIC CYTOPATHOLOGY, 2001, 24 (04) :233-239
[9]  
BROERS JLV, 1993, AM J PATHOL, V143, P211
[10]   p53 represses ribosomal gene transcription [J].
Budde, A ;
Grummt, I .
ONCOGENE, 1999, 18 (04) :1119-1124
12345678910