A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

被引：227
|
作者：
Bruenn, JA [1 ]
机构：
[1] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA
[2] Hauptman Woodward Med Res Inst, Buffalo, NY 14203 USA
来源：
NUCLEIC ACIDS RESEARCH | 2003年 / 31卷 / 07期
关键词：
D O I：
10.1093/nar/gkg277
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.
引用
收藏
页码：1821 / 1829
页数：9
相关论文
共 50 条
  • [31] Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases
    Liu, Qiaojie
    Wu, Jiqin
    Gong, Peng
    STAR PROTOCOLS, 2022, 3 (03):
  • [32] Factors regulating template switch in vitro by viral RNA-dependent RNA polymerases:: Implications for RNA-RNA recombination
    Kim, MJ
    Kao, C
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (09) : 4972 - 4977
  • [33] RNA silencing in Aspergillus nidulans independent of RNA-dependent RNA polymerases
    Hammond, TM
    Keller, NP
    GENETICS, 2005, 169 (02) : 607 - 617
  • [34] Inhibition of Viral RNA-Dependent RNA Polymerases by Nucleoside Inhibitors: An Illustration of the Unity and Diversity of Mechanisms
    Barik, Sailen
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (20)
  • [35] Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases
    Selisko, Barbara
    Papageorgiou, Nicolas
    Ferron, Francois
    Canard, Bruno
    VIRUSES-BASEL, 2018, 10 (02):
  • [36] Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation
    Shu, Bo
    Gong, Peng
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) : E4005 - E4014
  • [37] Fluorescent primer-based in vitro transcription system of viral RNA-dependent RNA polymerases
    Wang, Qiang
    Weng, Leiyun
    Jiang, Hongbing
    Zhang, Shijian
    Toyoda, Tetsuya
    ANALYTICAL BIOCHEMISTRY, 2013, 433 (02) : 92 - 94
  • [38] Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases
    Campagnola, Grace
    McDonald, Seth
    Beaucourt, Stephanie
    Vignuzzi, Marco
    Peersen, Olve B.
    JOURNAL OF VIROLOGY, 2015, 89 (01) : 275 - 286
  • [39] Motif D of Viral RNA-Dependent RNA Polymerases Determines Efficiency and Fidelity of Nucleotide Addition
    Yang, Xiaorong
    Smidansky, Eric D.
    Maksimchuk, Kenneth R.
    Lum, David
    Welch, Jesse L.
    Arnold, Jamie J.
    Cameron, Craig E.
    Boehr, David D.
    STRUCTURE, 2012, 20 (09) : 1519 - 1527
  • [40] Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases:: Implication for viral RNA synthesis
    Ranjith-Kumar, CT
    Gajewski, J
    Gutshall, L
    Maley, D
    Sarisky, RT
    Kao, CC
    JOURNAL OF VIROLOGY, 2001, 75 (18) : 8615 - 8623
12345