A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

被引：227
|
作者：
Bruenn, JA [1 ]
机构：
[1] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA
[2] Hauptman Woodward Med Res Inst, Buffalo, NY 14203 USA
来源：
NUCLEIC ACIDS RESEARCH | 2003年 / 31卷 / 07期
关键词：
D O I：
10.1093/nar/gkg277
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.
引用
收藏
页码：1821 / 1829
页数：9
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