Synthesis and Biological Evaluation of 1-Cyclohexyl Substituted 3-Aminopyrrolidine Derivatives as CC Chemokine Receptor 2 (CCR2) Antagonists

被引:1
|
作者
Lim, Jee Woong [1 ,5 ]
Na, Yongho [1 ]
Oak, Min-Ho [2 ]
Kim, Jong-Hoon [1 ,3 ]
Oh, Youna [1 ]
Lee, Seung-Woo [1 ]
Cho, Heeyeong [4 ]
Park, Woo-Kyu [4 ]
Choi, Gildon [4 ]
Kim, Kyoung Rak [1 ]
Kang, Jongmin [5 ]
机构
[1] Gyeonggi Bioctr, Suwon 443766, South Korea
[2] Hanwha Pharma, Ctr Res & Dev, Chunchon 200921, South Korea
[3] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea
[4] Korea Res Inst Chem Technol, Taejon 305600, South Korea
[5] Sejong Univ, Dept Chem, Seoul 143747, South Korea
关键词
Chemokine receptor; Antagonist; Inflammation; 3-Aminopyrrolidine;
D O I
10.5012/bkcs.2010.31.7.1827
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:1827 / 1828
页数:2
相关论文
共 50 条
  • [1] Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists
    Lim, Jee Woong
    Oh, Youna
    Kim, Jong-Hoon
    Oak, Min-Ho
    Na, Yongho
    Lee, Jung-Ok
    Lee, Seung-Woo
    Cho, Heeyeong
    Park, Woo-Kyu
    Choi, Gildon
    Kang, Jongmin
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (07) : 2099 - 2102
  • [2] Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2)
    Yang, Michael G.
    Xiao, Zili
    Shi, Qing
    Cherney, Robert J.
    Tebben, Andrew J.
    De Lucca, George V.
    Santella, Joseph B., III
    Mo, Ruowei
    Cvijic, Mary Ellen
    Zhao, Qihong
    Barrish, Joel C.
    Carter, Percy H.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (03) : 1384 - 1387
  • [3] Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists
    Xia, Mingde
    Hou, Cuifen
    Pollack, Scott
    Brackley, James
    DeMong, Duane
    Pan, Meng
    Singer, Monica
    Matheis, Michele
    Olini, Gil
    Cavender, Druie
    Wachter, Michael
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (21) : 5964 - 5968
  • [4] Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Brogan, John B.
    Mo, Ruowei
    Lo, Yvonne C.
    Yang, Gengjie
    Miller, Persymphonie B.
    Scherle, Peggy A.
    Molino, Bruce F.
    Carter, Percy H.
    Decicco, Carl P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (03) : 597 - 601
  • [5] Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Nelson, David J.
    Lo, Yvonne C.
    Yang, Gengjie
    Scherle, Peggy A.
    Jezak, Heather
    Solomon, Kimberly A.
    Carter, Percy H.
    Decicco, Carl P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (18) : 5063 - 5065
  • [6] γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Mo, Ruowei
    Meyer, Dayton T.
    Voss, Matthew E.
    Yang, Michael G.
    Santella, Joseph B., III
    Duncia, John V.
    Lo, Yvonne C.
    Yang, Gengjie
    Miller, Persymphonie B.
    Scherle, Peggy A.
    Zhao, Qihong
    Mandlekar, Sandhya
    Cvijic, Mary Ellen
    Barrish, Joel C.
    Decicco, Carl P.
    Carter, Percy H.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (08) : 2425 - 2430
  • [7] Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Mo, Ruowei
    Meyer, Dayton T.
    Pechulis, Anthony D.
    Guaciaro, Michael A.
    Lo, Yvonne C.
    Yang, Gengjie
    Miller, Persymphonie B.
    Scherle, Peggy A.
    Zhao, Qihong
    Cvijic, Mary Ellen
    Barrish, Joel C.
    Decicco, Carl P.
    Carter, Percy H.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (19) : 6181 - 6184
  • [8] Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma
    Lagu, Bharat
    Gerchak, Chrissy
    Pan, Meng
    Hou, Cuifen
    Singer, Monica
    Malaviya, Ravi
    Matheis, Michele
    Olini, Gil
    Cavender, Druie
    Wachter, Michael
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (15) : 4382 - 4386
  • [9] Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2)
    Carter, Percy H.
    Brown, Gregory D.
    Friedrich, Sarah R.
    Cherney, Robert J.
    Tebben, Andrew J.
    Lo, Yvonne C.
    Yang, Gengjie
    Jezak, Heather
    Solomon, Kimberly A.
    Scherle, Peggy A.
    Decicco, Carl P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (19) : 5455 - 5461
  • [10] Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Mo, Ruowei
    Meyer, Dayton T.
    Voss, Matthew E.
    Lo, Yvonne C.
    Yang, Gengjie
    Miller, Persymphonie B.
    Scherle, Peggy A.
    Tebben, Andrew J.
    Carter, Percy H.
    Decicco, Carl P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (13) : 3418 - 3422