SYNTHESIS AND FUNCTIONALIZATION OF THE 3-(1,3,4-OXADIAZOL-2-YL)-1H-INDOLES

被引：1

作者：

Alyab'ev, S. B. ^{[1
]}

Kravchenko, D. V. ^{[1
]}

Ivashchenko, A. V. ^{[1
]}

机构：

[1] Res Inst Chem Divers, Chimki 141401, Moscow Region, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2009年 / 45卷 / 10期

关键词：

3-(1,3,4-oxadiazol-2-yl)-1H-indoles; 3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids; orthoesters; amide library; intramolecular cyclization; ANTIMICROBIAL ACTIVITY; DERIVATIVES; ANTAGONISTS; INDOLE;

D O I：

10.1007/s10593-010-0418-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modified method is proposed for the preparative synthesis of 3-(1,3,4-oxadiazol-2-yl)-1H-indoles in high yield. We are the first to demonstrate the functionalization of this heterocyclic system by alkylation. In particular, syntheses are reported for [3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids and their amide derivatives.

引用

页码：1270 / 1275

页数：6

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