SYNTHESIS AND FUNCTIONALIZATION OF THE 3-(1,3,4-OXADIAZOL-2-YL)-1H-INDOLES

被引：1
|
作者：
Alyab'ev, S. B. [1 ]
Kravchenko, D. V. [1 ]
Ivashchenko, A. V. [1 ]
机构：
[1] Res Inst Chem Divers, Chimki 141401, Moscow Region, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2009年 / 45卷 / 10期
关键词：
3-(1,3,4-oxadiazol-2-yl)-1H-indoles; 3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids; orthoesters; amide library; intramolecular cyclization; ANTIMICROBIAL ACTIVITY; DERIVATIVES; ANTAGONISTS; INDOLE;
D O I：
10.1007/s10593-010-0418-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A modified method is proposed for the preparative synthesis of 3-(1,3,4-oxadiazol-2-yl)-1H-indoles in high yield. We are the first to demonstrate the functionalization of this heterocyclic system by alkylation. In particular, syntheses are reported for [3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids and their amide derivatives.
引用
收藏
页码：1270 / 1275
页数：6
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