γδ T cells regulate the intestinal response to nutrient sensing

被引：103

作者：

Sullivan, Zuri A. ^{[1
,10
]}

Khoury-Hanold, William ^{[1
]}

Lim, Jaechul ^{[1
]}

Smillie, Chris ^{[2
]}

Biton, Moshe ^{[2
,11
]}

Reis, Bernardo S. ^{[3
]}

Zwick, Rachel K. ^{[4
,5
]}

Pope, Scott D. ^{[1
,6
]}

Israni-Winger, Kavita ^{[1
]}

Parsa, Roham ^{[3
]}

Philip, Naomi H. ^{[1
]}

Rashed, Saleh ^{[1
]}

Palm, Noah ^{[1
]}

Wang, Andrew ^{[1
,7
]}

Mucida, Daniel ^{[3
]}

Regev, Aviv ^{[2
,8
,9
,12
]}

Medzhitov, Ruslan ^{[1
,6
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Broad Inst, Klarman Cell Observ, Cambridge, MA USA

[3] Rockefeller Univ, Lab Mucosal Immunol, 1230 York Ave, New York, NY 10021 USA

[4] Univ Calif San Francisco, Program Craniofacial Biol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Orofacial Sci, San Francisco, CA 94143 USA

[6] Howard Hughes Med Inst, New Haven, CT 06510 USA

[7] Yale Univ, Sch Med, Dept Med, Div Rheumatol, New Haven, CT 06510 USA

[8] MIT, Dept Biol, David H Koch Inst Integrat Canc Res Mit, Cambridge, MA USA

[9] Howard Hughes Med Inst, Cambridge, MA USA

[10] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[11] Weizmann Inst Sci, Dept Biol Regulat, IL-7610001 Rehovot, Israel

[12] Genentech Inc, 1 DNA Way, San Francisco, CA USA

来源：

SCIENCE | 2021年 / 371卷 / 6535期

基金：

美国国家科学基金会;

关键词：

INNATE LYMPHOID-CELLS; SUCRASE-ISOMALTASE; FAT DIET; RNA-SEQ; SINGLE; HOMEOSTASIS; EXPRESSION; IMMUNITY; PROTEIN;

D O I：

10.1126/science.aba8310

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intestine is a site of direct encounter with the external environment and must consequently balance barrier defense with nutrient uptake. To investigate how nutrient uptake is regulated in the small intestine, we tested the effect of diets with different macronutrient compositions on epithelial gene expression. We found that enzymes and transporters required for carbohydrate digestion and absorption were regulated by carbohydrate availability. The "on-demand" induction of this machinery required gamma delta T cells, which regulated this program through the suppression of interleukin-22 production by type 3 innate lymphoid cells. Nutrient availability altered the tissue localization and transcriptome of gamma delta T cells. Additionally, transcriptional responses to diet involved cellular remodeling of the epithelial compartment. Thus, this work identifies a role for gamma delta T cells in nutrient sensing.

引用

页码：1223 / +

页数：39

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