The role of short-chain fatty acids in Clostridioides difficile infection: A review

被引：15
作者：
Ouyang, Zi-rou [1 ,2 ]
Niu, Xiao-ran [1 ,2 ]
Wang, Wei-gang [1 ,2 ]
Zhao, Jian-hong [1 ,2 ]
机构：
[1] Hebei Med Univ, Hosp 2, 215 Hepingxi Rd, Shijiazhuang 050000, Hebei Province, Peoples R China
[2] Hebei Prov Ctr Clin Labs, 215 Hepingxi Rd, Shijiazhuang 050000, Hebei Province, Peoples R China
来源：
ANAEROBE | 2022年 / 75卷
关键词：
Clostridioides difficile; Short-chain fatty acids; Fecal microbiota transplantation; Immunity; Inflammation; Intestinal microbiota; HISTONE DEACETYLASE 6; DIVERSION COLITIS; GUT MICROBIOTA; DOUBLE-BLIND; BUTYRATE; BACTERIA; HEALTH; TOXIN;
D O I：
10.1016/j.anaerobe.2022.102585
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Clostridioides difficile is a Gram-positive, obligate anaerobic, spore-producing intestinal opportunistic pathogen. CDI outbreaks in Europe and the Americas in recent years are a major health concern. Intestinal short-chain fatty acids (SCFAs) are an important energy source for colonic epithelial cells, and the roles of SCFAs in reducing intestinal inflammation, inhibiting intestinal tumors, and regulating gut microbial homeostasis are being actively researched. Furthermore, SCFAs attenuate CDI or directly inhibit C. difficile growth through different pathways in vivo and in vitro. This review assesses the role of SCFAs in CDI and discusses the potential use of these molecules as therapeutic targets for CDI.(c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页数：5
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