This paper is concerned with CDMA applied to personal and mobile communications on a global basis using multiple low earth orbital satellites (LEOS). we focus our attention on some unique aspects of LEOS systems and discuss their influences on the CDMA system performance as well as the techniques for coping with these aspects. We deal with three kinds of important items that are unique to LEOS systems; Doppler frequency shift due to satellite movement, propagation delay affecting packetized data transmission and geographical nonunifomity in traffic.