Ankylosing spondylitis:: a β2m-deposition disease?

被引：41
作者：
Uchanska-Ziegler, B [1 ]
Ziegler, A [1 ]
机构：
[1] Humboldt Univ, Klinikum Charite, Inst Immunogenet, D-14050 Berlin, Germany
来源：
TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 02期
关键词：
D O I：
10.1016/S1471-4906(02)00028-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To explain the strong association between HLA-B27 and ankylosing spondylitis, we suggest that the release Of beta(2)-microglobulin (beta(2)m) from a subpopulation of cell surf ace-expressed HLA-B27 molecules leads to beta(2)m-deposition within synovia and to the initiation of an inflammatory process, which culminates in destructive spondyloarthropathy.
引用
收藏
页码：73 / 76
页数：4
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