Ankylosing spondylitis:: a β2m-deposition disease?

被引：41

作者：

Uchanska-Ziegler, B ^{[1
]}

Ziegler, A ^{[1
]}

机构：

[1] Humboldt Univ, Klinikum Charite, Inst Immunogenet, D-14050 Berlin, Germany

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 02期

关键词：

D O I：

10.1016/S1471-4906(02)00028-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To explain the strong association between HLA-B27 and ankylosing spondylitis, we suggest that the release Of beta(2)-microglobulin (beta(2)m) from a subpopulation of cell surf ace-expressed HLA-B27 molecules leads to beta(2)m-deposition within synovia and to the initiation of an inflammatory process, which culminates in destructive spondyloarthropathy.

引用

页码：73 / 76

页数：4

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