Design, synthesis and structure-activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

被引：37

作者：

Sajith, Ayyiliath M. ^{[1
,4
]}

Khader, K. K. Abdul ^{[2
]}

Joshi, Nithin ^{[3
]}

Reddy, Manchala Nageswar ^{[8
]}

Padusha, M. Syed Ali ^{[2
]}

Nagaswarupa, H. P. ^{[5
]}

Joy, M. Nibin ^{[6
]}

Bodke, Yadav D. ^{[6
]}

Karuvalam, Ranjith P. ^{[7
]}

Banerjee, Rinti ^{[3
]}

Muralidharan, A. ^{[1
,4
]}

Rajendra, R. ^{[8
]}

机构：

[1] Kannur Univ, Dept Chem, Nehru Arts & Sci Coll, Kannur, India

[2] Bharathidasan Univ, Jamal Mohamed Coll, Post Grad & Res Dept Chem, Tiruchirappalli, India

[3] IIT Mumbai, Dept Biosci & Bioengn, Bombay, Maharashtra, India

[4] Kannur Univ, Kasargod Govt Coll, Post Grad & Res Dept Chem, Kannur, Kerala, India

[5] East West Inst Technol, Dept Chem, Res Ctr, Bangalore, Karnataka, India

[6] Kuvempu Univ, Dept PG Studies & Res Ind Chem, Jnana Sahyadri, Shimoga, Karnataka, India

[7] Kannur Univ, Sch Chem Sci, Kannur, Kerala, India

[8] Cent Univ Kerala, Periya, Kerala, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 89卷

关键词：

Chemotherapy; Cytotoxic studies; Suzuki coupling; Imidazo[4,5-b]pyridine analogues; BOND-FORMING REACTIONS; ANTICANCER AGENTS; PRIVILEGED STRUCTURES; DERIVATIVES; INHIBITORS; BIOISOSTERISM; NUCLEOSIDES; ISOXAZOLINE; EXPLORATION; MECHANISM;

D O I：

10.1016/j.ejmech.2014.10.037

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Drug resistance to chemotherapeutic agents paved the way to develop novel synthetic molecules which are active on MDR cancer cell lines. Regio-isomeric imidazo[4,5-b]pyridine analogues were synthesized and evaluated for their cytotoxic activity against a range of cancer cell lines. The structure activity relationship (SAR) studies of the imidazopyridine analogues are also described. Analogue 6b displayed strong cytotoxicity and good microsomal stability. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：21 / 31

页数：11

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