Zinc is involved in regulation of secretion from intestinal epithelium in weaned piglets

被引：4
|
作者：
Carlson, D.
Sehested, J.
Feng, Z.
Poulsen, H. D.
机构：
[1] Univ Aarhus, Fac Agr Sci, Res Ctr Foulum, Dept Anim Hlth Welfare & Nutr, Tjele 8830, Denmark
[2] Minist Agr, Feed Ind Ctr, Beijing, Peoples R China
来源：
LIVESTOCK SCIENCE | 2007年 / 108卷 / 1-3期
关键词：
ussing chamber; serotonin (5-HT); vasoactive intestinal polypeptide (VIP); forskolin (FSK);
D O I：
10.1016/j.livsci.2007.01.026
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
The objective was to study the effect of serosal zinc (Zn) on intestinal chloride (Cl-) secretion in vitro by the Ussing chamber technique. The secretagogues used to stimulate Cl- secretion were serotonin (5-HT), vasoactive intestinal polypeptide (VIP) and forskolin (FSK). In addition correlations between organ and plasma Zn levels vs. the responses to 5-HT were studied. The results revealed an attenuating effect of scrosal Zn on the secretory response to 5-HT, VIP and FSK. Furthermore, negative correlations between secretory responses to 5-HT vs. ADG and plasma Zn concentrations were found, whereas the responses to 5-HT did not correlate to the Zn concentration in liver or intestinal mucosa. It is suggested, that dietary Zn reduces diarrhoea directly through a regulatory role of serosal Zn on Cl- secretion and indirectly by improving the nutritional status, which may stabilize the function of the intestinal epithelium. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：45 / 48
页数：4
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