3D Bioprinting Constructs to Facilitate Skin Regeneration

被引：61

作者：

Daikuara, Luciana Y. ^{[1
]}

Chen, Xifang ^{[1
]}

Yue, Zhilian ^{[1
]}

Skropeta, Danielle ^{[2
,3
]}

Wood, Fiona M. ^{[4
,5
,6
,7
]}

Fear, Mark W. ^{[6
,7
]}

Wallace, Gordon G. ^{[1
]}

机构：

[1] Univ Wollongong, ARC Ctr Excellence Elect Sci, Intelligent Polymer Res Inst, Innovat Campus, Wollongong, NSW, Australia

[2] Univ Wollongong, Fac Sci Med & Hlth SMAH & Mol Horizons, Sch Chem & Mol Biosci, Wollongong, NSW, Australia

[3] Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia

[4] Univ Western Australia, Sch Biomed Sci, Crawley, WA, Australia

[5] Perth Childrens Hosp, Fiona Stanley Hosp, Burns Serv Western Australia, Nedlands, WA, Australia

[6] Fiona Stanley Hosp, Fiona Wood Fdn, Murdoch, WA, Australia

[7] Univ Western Australia, Burn Injury Res Unit, Crawley, WA, Australia

来源：

ADVANCED FUNCTIONAL MATERIALS | 2022年 / 32卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

3D bioprinting; bioinks; biomaterial; skin cells; skin equivalent; CULTURED EPITHELIAL AUTOGRAFT; EPIDERMAL-GROWTH-FACTOR; PLATELET-RICH PLASMA; MESENCHYMAL STEM-CELLS; DIABETIC FOOT ULCERS; IN-VITRO; BIOFABRICATION STRATEGIES; FUNCTIONAL-PROPERTIES; CHRONIC WOUNDS; LEG ULCERS;

D O I：

10.1002/adfm.202105080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the last decade, the advent of 3D printing for tissue engineering and regenerative medicine has engendered great interest for those involved in skin repair and regeneration. 3D bioprinting allows spatial distribution of skin cells into predefined custom-made structures to produce living skin mimics on the bench for grafting or drug testing. The key aspect of 3D bioprinting lies in the formulation of printable bioinks serving as matrix mimics to house skin cells, alongside an appropriate combination of cells. In this review, bioink formulations, cell combinations, as well as manufacturing methods exploited to develop 3D bioprinted constructs for skin regeneration are summarized. Issues to do with the selection of suitable materials and cells to ensure the functionality of the resulting skin constructs and fabrication of skin appendages are also addressed.

引用

页数：24

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