A total synthesis of the racemic sesquiterpene parvifoline

被引：26
作者：
Covarrubias-Zúñiga, A
Cantú, F
Maldonado, LA
机构：
[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
[2] Univ Nacl Autonoma Mexico, Fac Quim, Div Estudios Posgrado, Mexico City 04510, DF, Mexico
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 09期
关键词：
D O I：
10.1021/jo972092p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A total synthesis of the sesquiterpene (+/-)-parvifoline 1 from the symmetrical naphthalene 4 is reported. The key step of the synthesis was a Stork-Landesman two-carbon ring expansion of beta-tetralone 5, which affords 9a with the complete framework of the target. Although many reactions are involved in the sequence, the whole synthesis can be executed in only five synthetic operations and in approximate to 18% overall yield.
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页码：2918 / 2921
页数：4
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