Effective anti-BCMA retreatment in multiple myeloma

被引：33

作者：

Gazeau, Nicolas ^{[1
]}

Beauvais, David ^{[1
]}

Yakoub-Agha, Ibrahim ^{[1
,2
]}

Mitra, Suman ^{[3
,4
]}

Campbell, Timothy B. ^{[5
]}

Facon, Thierry ^{[1
]}

Manier, Salomon ^{[1
,3
,4
]}

机构：

[1] Lille Univ, Dept Hematol, CHU Lille, Lille, France

[2] Lille Univ, INSERM, Infinite, U1286, Lille, France

[3] Lille Univ, Canther, INSERM, UMR S1277, Lille, France

[4] Lille Univ, CNRS, UMR9020, Lille, France

[5] Bristol Myers Squibb, Princeton, NJ USA

来源：

BLOOD ADVANCES | 2021年 / 5卷 / 15期

关键词：

BAFF; APRIL;

D O I：

10.1182/bloodadvances.2021004176

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recent emergence of anti-B-cell maturation antigen (BCMA) therapies holds great promise in multiple myeloma (MM). These include chimeric antigen receptor (CAR) T cells, bispecific antibodies, and antibody-drug conjugates. Their development in clinical trials and further approval are changing the strategy for treating MM. Considering that a cure has not been reached, a central question in the coming years will be the possibility of using these therapies sequentially. Here, we report 2 cases of the serial use of anti-BCMA therapies with parallel monitoring of BCMA expression and anti-CAR antibodies. We further discuss recent data from clinical studies that have informed us about the different mechanisms of resistance to anti-BCMA therapies, including antigen escape, BCMA shedding, anti-drug antibodies, T-cell exhaustion, and the emergence of an immunosup-pressive microenvironment. This knowledge will be essential to help guide the strategy of serial treatments with anti-BCMA therapies.

引用

页码：3016 / 3020

页数：5

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