GENETIC MODIFICATION OF STEM CELLS FOR EX VIVO GENE THERAPY

被引：0

作者：

Rozwadowska, Natalia ^{[1
]}

Kurpisz, Maciej ^{[1
]}

机构：

[1] PAN, Inst Genet Czlowieka, PL-60479 Poznan, Poland

来源：

POSTEPY BIOLOGII KOMORKI | 2010年 / 37卷 / 01期

关键词：

stem cells; genetic modification; vectors; organ regeneration; PARKINSONS-DISEASE; CEREBRAL-ISCHEMIA; PROGENITOR CELLS; RETINOIC ACID; GROWTH-FACTOR; DELIVERY; TRANSPLANTATION; VECTORS; EXPRESSION; MODEL;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Progress of research on stem cells including their genetic modifications allowed to obtain very promising results. However,one of the main barriers that (ex vivo) therapy has been encountered was delivery of genetic construct to the target cell As well plasmids (delivered with using physico-chemical methods) its viral vectors have its prominent place at preparations aimed to implant genetically modified stem cells (auto- or allogenic origin) to recipient organ. Genetic modifications involve therapeutic, reported or regulatory genes which may help to Implantation of stem cells itself. to limit Inflammatory process or apoptosis. to enhance physiological Function of damaged organs/tissues This review presents it progress in Invention of novel genetic constructs and indicates main trends for application of genetically modified stem cells as therapeutic agents for either congenital or acquired pathologies

引用

页码：253 / 269

页数：17

共 67 条

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