A nomogram to predict prognosis for gastric cancer with peritoneal dissemination

被引：12
作者：
Chen, Shi [1 ,2 ]
Chen, Xijie [1 ,2 ]
Nie, Runcong [3 ]
Yang, Liying Ou [4 ]
Liu, Aihong [1 ,2 ]
Li, Yuanfang [3 ]
Zhou, Zhiwei [3 ]
Chen, Yingbo [3 ]
Peng, Junsheng [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, 26 Yuancun Erheng Rd, Guangzhou 510655, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastrointestinal Surg, 26 Yuancun Erheng Rd, Guangzhou 510655, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Ctr Canc, Dept Gastropancreat Surg, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Ctr Canc, Dept Intens Care, Guangzhou 510060, Guangdong, Peoples R China
来源：
CHINESE JOURNAL OF CANCER RESEARCH | 2018年 / 30卷 / 04期
关键词：
Gastric cancer; prognosis; peritoneal dissemination; nomogram; CURATIVE RESECTION; GASTROESOPHAGEAL JUNCTION; PALLIATIVE GASTRECTOMY; EXTERNAL VALIDATION; SURVIVAL; ADENOCARCINOMA; METASTASIS; ESOPHAGUS;
D O I：
10.21147/j.issn.1000-9604.2018.04.08
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To identify independent prognostic factors to be included in a nomogram to predict the prognosis of gastric cancer patients with peritoneal dissemination. Methods: This is a retrospective study on 684 patients with a histological diagnosis of gastric cancer with peritoneal dissemination from the Sun Yat-sen University Cancer Center as the development set, and 62 gastric cancer patients from the Sixth Affiliated Hospital of Sun Yat-sen University as the validation group. Chi-square test and Cox regression analysis were used to compare the clinicopathological variables and the prognosis of gastric cancer patients with peritoneal dissemination. The Harrell's concordance index (C-index) and calibration curve were determined for comparisons of predictive ability of the nomogram. Results: Univariate and multivariate analyses showed that serum carcinoembryonic antigen (CEA) level (P=0.032), ascites grading (P=0.008), presence of extraperitoneal metastasis (P<0.001), seeding status (P=0.016) and performance status (P=0.009) were independent prognostic factors for gastric cancer patients with peritoneal dissemination in the development set. The nomogram model was constructed using these five factors. Internal validation showed that the C-index of the model was 0.641. For the external validation, the C-index of this model was 0.709. Conclusion: We developed and validated a nomogram to predict the prognosis for gastric cancer patients with peritoneal dissemination. This nomogram may play an important clinical role in guiding palliative therapy for these types of patients, although it may need more data for optimization.
引用
收藏
页码：449 / 459
页数：11
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