Transgenic mouse expressing a full-length hepatitis C virus cDNA

被引：24

作者：

Matsuda, J

Suzuki, M

Nozaki, C

Shinya, N

Tashiro, K

Mizuno, K

Uchinuno, Y

Yamamura, K

机构：

[1] Kikuchi Res Ctr, Chemo Sero Therapeut Res Inst, Good Lab Practice GLP Ctr, Dept Pathol, Kumamoto 86912, Japan

[2] Kumamoto Univ, Inst Mol Embryol & Genet, Dept Dev Genet, Kumamoto 862, Japan

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1998年 / 89卷 / 02期

关键词：

hepatitis C virus; transgenic mouse; human serum amyloid P component (hSAP) promoter;

D O I：

10.1111/j.1349-7006.1998.tb00543.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatitis C virus (HCV), a major causative agent of post transfusion non-A, non-B hepatitis (NANBH), can only infect humans and chimpanzees, We produced nine transgenic mouse lines carrying a full-length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver-specific expression, In one of these lines HCV mRNA and HCV core protein were detected in the liver of the transgenic mouse, although the levels of expression were very low. In addition, HCV-related antibody was detected in the serum.

引用

页码：150 / 158

页数：9

共 50 条

[1] EXPRESSION AND REPLICATION OF HEPATITIS-B VIRUS GENOME IN TRANSGENIC MICE
ARAKI, K
MIYAZAKI, J
HINO, O
TOMITA, N
CHISAKA, O
MATSUBARA, K
YAMAMURA, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (01) : 207 - 211
[2] CORRELATION OF TISSUE-SPECIFIC METHYLATION WITH GENE INACTIVITY IN HEPATITIS-B VIRUS TRANSGENIC MICE
ARAKI, K
AKAGI, K
MIYAZAKI, J
MATSUBARA, K
YAMAMURA, K
[J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1990, 81 (12): : 1265 - 1271
[3] DEVELOPMENT OF 2 TYPES OF HEPATOCELLULAR-CARCINOMA IN TRANSGENIC MICE CARRYING THE SV40 LARGE T-ANTIGEN GENE
ARAKI, K
HINO, O
MIYAZAKI, J
YAMAMURA, K
[J]. CARCINOGENESIS, 1991, 12 (11) : 2059 - 2062
[4] Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
Barba, G
Harper, F
Harada, T
Kohara, M
Goulinet, S
Matsuura, Y
Eder, G
Schaff, Z
Chapman, MJ
Miyamura, T
Brechot, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) : 1200 - 1205
[5] A TRANSGENIC MOUSE MODEL OF THE CHRONIC HEPATITIS-B SURFACE-ANTIGEN CARRIER STATE
CHISARI, FV
PINKERT, CA
MILICH, DR
FILIPPI, P
MCLACHLAN, A
PALMITER, RD
BRINSTER, RL
[J]. SCIENCE, 1985, 230 (4730) : 1157 - 1160
[6] GENETIC ORGANIZATION AND DIVERSITY OF THE HEPATITIS-C VIRUS
CHOO, QL
RICHMAN, KH
HAN, JH
BERGER, K
LEE, C
DONG, C
GALLEGOS, C
COIT, D
MEDINASELBY, A
BARR, PJ
WEINER, AJ
BRADLEY, DW
KUO, G
HOUGHTON, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) : 2451 - 2455
[7] CRBIER B, 1995, J GEN VIROL, V76, P2485
[8] Dash S, 1997, AM J PATHOL, V151, P363
[9] DIBISCEGLIE AM, 1991, HEPATOLOGY, V14, P969, DOI 10.1016/0270-9139(91)90113-A
[10] THE HEPATITIS-C VIRUS ENCODES A SERINE PROTEASE INVOLVED IN PROCESSING OF THE PUTATIVE NONSTRUCTURAL PROTEINS FROM THE VIRAL POLYPROTEIN PRECURSOR
ECKART, MR
SELBY, M
MASIARZ, F
LEE, C
BERGER, K
CRAWFORD, K
KUO, C
KUO, G
HOUGHTON, M
CHOO, QL
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (02) : 399 - 406

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