Anticonvulsants for Psychiatric Disorders in Children and Adolescents: A Systematic Review of Their Efficacy

被引:11
|
作者
Davico, Chiara [1 ]
Canavese, Carlotta [1 ]
Vittorini, Roberta [1 ]
Gandione, Marina [1 ]
Vitiello, Benedetto [1 ]
机构
[1] Univ Turin, Dept Publ Hlth & Pediat Sci, Div Child & Adolescent Neuropsychiat, Turin, Italy
来源
FRONTIERS IN PSYCHIATRY | 2018年 / 9卷
关键词
anticonvulsants; children; psychiatric; bipolar; aggression; clinical trial; PLACEBO-CONTROLLED TRIAL; BIPOLAR I DISORDER; DOUBLE-BLIND; DIVALPROEX SODIUM; CONDUCT DISORDER; LITHIUM; CARBAMAZEPINE; RISPERIDONE; AGGRESSION; VALPROATE;
D O I
10.3389/fpsyt.2018.00270
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Aim: Anticonvulsant medications are frequently used in clinical practice to treat psychiatric disorders in children and adolescents, but the evidence for their efficacy is uncertain. We conducted a systematic review of published randomized controlled trials (RCT) that assessed the psychiatric benefit of anticonvulsants in patients under 18 years of age. Method: The Medline, Scopus, Web of Science, and ClinicalTrials.gov databases were systematically searched for peer-reviewed primary publications of RCTs with a minimum of 10 patients per treatment arm through December 2017. Results: Out of 355 identified non-duplicative publications, 24 met the inclusion criteria. Most RCTs were to treat bipolar disorder (n = 12) or manage recurrent aggression (n = 9). Few (n = 3) had both a multisite design and adequate statistical power. Valproate was the most frequently studied anticonvulsant (n = 15). Out of three placebo-controlled RCTs of valproate in bipolar disorder, none showed efficacy. In four RCTs, valproate was inferior to the antipsychotic risperidone. In several small, single-site RCTs, valproate and sulthiame were better than placebo for the management of recurrent aggression. Conclusions: Currently available RCTs do not support the efficacy of anticonvulsants as mood stabilizers in children. There is some preliminary evidence from small RCTs of the efficacy of some anticonvulsants in the control of aggression and behavioral dyscontrol in conduct disorder, autism, and intellectual disability.
引用
收藏
页数:8
相关论文
共 50 条
  • [1] Review of the Efficacy and Safety of Cannabidiol with a Focus on Children and Adolescents in the Treatment of Psychiatric Symptoms and Disorders
    Sun, Amanda Yuan
    Sullivan, Aimee
    Leffler, Jarrod M.
    Hammond, Christopher J.
    Hulvershorn, Leslie
    Miller, Leslie
    ADOLESCENT PSYCHIATRY, 2023, 13 (03) : 143 - 159
  • [2] BARRIERS AND FACILITATORS TO PHYSICAL ACTIVITY AMONG CHILDREN AND ADOLESCENTS WITH PSYCHIATRIC DISORDERS: A SYSTEMATIC REVIEW
    Hickingbotham, Madison R.
    Bowling, April B.
    Wong, Catherine J.
    ANNALS OF BEHAVIORAL MEDICINE, 2021, 55 : S75 - S75
  • [3] Efficacy of cannabinoids in neurodevelopmental and neuropsychiatric disorders among children and adolescents: a systematic review
    Rice, Lauren J.
    Cannon, Lisa
    Dadlani, Navin
    Cheung, Melissa Mei Yin
    Einfeld, Stewart L.
    Efron, Daryl
    Dossetor, David R.
    Elliott, Elizabeth J.
    EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2024, 33 (02) : 505 - 526
  • [4] Efficacy of cannabinoids in neurodevelopmental and neuropsychiatric disorders among children and adolescents: a systematic review
    Lauren J. Rice
    Lisa Cannon
    Navin Dadlani
    Melissa Mei Yin Cheung
    Stewart L. Einfeld
    Daryl Efron
    David R. Dossetor
    Elizabeth J. Elliott
    European Child & Adolescent Psychiatry, 2024, 33 : 505 - 526
  • [5] Efficacy of tiapride in the treatment of psychiatric disorders: A systematic review
    Zangani, Caroline
    Giordano, Barbara
    Stein, Hans-Christian
    Bonora, Stefano
    Ostinelli, Edoardo Giuseppe
    D'Agostino, Armando
    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2022, 37 (05)
  • [6] Psychiatric Disorders in Detained Male Adolescents: A Systematic Literature Review
    Colins, Olivier
    Vermeiren, Robert
    Vreugdenhil, Coby
    van den Brink, Wim
    Doreleijers, Theo
    Broekaert, Erik
    CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2010, 55 (04): : 255 - 263
  • [7] Management of psychiatric disorders in children and adolescents with atypical antipsychoticsA systematic review of published clinical trials
    Peter S. Jensen
    Jan Buitelaar
    Gahan J. Pandina
    Carin Binder
    Magali Haas
    European Child & Adolescent Psychiatry, 2007, 16 : 104 - 120
  • [8] Management of psychiatric disorders in children and adolescents with atypical antipsychotics - A systematic review of published clinical trials
    Jensen, Peter S.
    Buitelaar, Jan
    Pandina, Gahan J.
    Binder, Carin
    Haas, Magali
    EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2007, 16 (02) : 104 - 120
  • [9] The efficacy of anticonvulsants on orofacial pain: a systematic review
    Martin, Wilhelmus J. J. M.
    Forouzanfar, Tymour
    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 2011, 111 (05): : 627 - 633
  • [10] Empirical evidence for the use of lithium and anticonvulsants in children with psychiatric disorders
    Lopez-Larson, Melissa
    Frazier, Jean A.
    HARVARD REVIEW OF PSYCHIATRY, 2006, 14 (06) : 285 - 304