Exosome: a new perspective in colorectal cancer therapy

被引：0

作者：

Mao, Deli ^{[1
]}

Zhang, Zhe ^{[1
]}

Zhao, Xin ^{[1
]}

Dong, Xiaoqiang ^{[1
]}

机构：

[1] Soochow Univ, Dept Gen Surg, Affiliated Hosp 1, Suzhou, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2019年 / 12卷 / 11期

基金：

美国国家科学基金会;

关键词：

Exosomes; colorectal cancer; treatment; drug resistance; metastasis; EMERGING ROLE; DELIVERY; PROMOTE; CELLS; SERUM; DIFFERENTIATION; MICROVESICLES; PROLIFERATION; RECURRENCE; EXPRESSION;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Exosomes refer to the mediators between tumor cells and matrix information exchange. With the transfer of proteins and RNA mediated by exosomes, the microenvironment of tumors varies. Tumor-derived exosomes (TEXs) affect the progress, the treatment and the prognosis of colorectal cancer (CRC). In the present review, the latest research results of CRC-related exosomes in recent years are summarized, covering exosome-induced epithelial-mesenchymal cell transformation of cancer cells. They can potentiate angiogenesis, tumor cell movement, metastasis and migration and suppress immune response, and cancer chemotherapy resistance. Besides, the use of exosomes as carriers in cancer targeting therapy, and the safety and reliability of developing cancer vaccines with exosomes separated from body fluids are discussed as well. Lastly, the application prospects of exosomes as biomarkers in CRC diagnosis and prognosis are prospected.

引用

页码：12619 / 12632

页数：14

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