The epigenetics of tumour initiation: cancer stem cells and their chromatin

被引：49

作者：

Avgustinova, Alexandra ^{[1
]}

Aznar Benitah, Salvador ^{[1
,2
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2016年 / 36卷

基金：

欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; E-CADHERIN REPRESSION; BREAST-CANCER; EZH2; PLASTICITY; IDENTIFICATION; TRANSCRIPTION; DEMETHYLASES; ORGANIZATION; EQUILIBRIUM;

D O I：

10.1016/j.gde.2016.01.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer stem cells (CSCs) have been identified in various tumours and are defined by their potential to initiate tumours upon transplantation, self-renew and reconstitute tumour heterogeneity. Modifications of the epigenome can favour tumour initiation by affecting genome integrity, DNA repair and tumour cell plasticity. Importantly, an in-depth understanding of the epigenomic alterations underlying neoplastic transformation may open new avenues for chromatin-targeted cancer treatment, as these epigenetic changes could be inherently more amenable to inhibition and reversal than hardwired genomic alterations. Here we discuss how CSC function is affected by chromatin state and epigenomic instability.

引用

页码：8 / 15

页数：8

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