Prostate cancer in omics era

被引:8
作者
Gholami, Nasrin [1 ]
Haghparast, Amin [2 ]
Alipourfard, Iraj [3 ]
Nazari, Majid [4 ,5 ]
机构
[1] Tabriz Univ Med Sci, Hematol & Oncol Res Ctr, Tabriz, Iran
[2] GenomeFan, Tehran, Iran
[3] Univ Silesia, Inst Biol Biotechnol & Environm Protect, Fac Nat Sci, Katowice, Poland
[4] Shahid Sadoughi Univ Med Sci, Dept Med Genet, Fac Med, Yazd, Iran
[5] POB 14155-6117, Shiraz, Iran
关键词
Prostate cancer; Genomics; Proteomics; Metabolomics; Diagnosis; Computational algorithm; GENE-EXPRESSION; DNA METHYLATION; ANALYSES REVEAL; SEMINAL PLASMA; EARLY-ONSET; METABOLOMICS; BIOMARKER; DATABASE; IDENTIFICATION; TRANSCRIPTOME;
D O I
10.1186/s12935-022-02691-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Recent advances in omics technology have prompted extraordinary attempts to define the molecular changes underlying the onset and progression of a variety of complex human diseases, including cancer. Since the advent of sequencing technology, cancer biology has become increasingly reliant on the generation and integration of data generated at these levels. The availability of multi-omic data has transformed medicine and biology by enabling integrated systems-level approaches. Multivariate signatures are expected to play a role in cancer detection, screening, patient classification, assessment of treatment response, and biomarker identification. This review reports current findings and highlights a number of studies that are both novel and groundbreaking in their application of multi Omics to prostate cancer.
引用
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页数:15
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