Ferrocene-Based Compounds with Antimalaria/Anticancer Activity

被引：114

作者：

Peter, Sijongesonke ^{[1
]}

Aderibigbe, Blessing Atim ^{[1
]}

机构：

[1] Univ Ft Hare, Dept Chem, Alice Campus, ZA-5700 Eastern Cape, South Africa

来源：

MOLECULES | 2019年 / 24卷 / 19期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

organometallics; malaria; cancer; ferrocene compounds; ferroquine; VITRO ANTIMALARIAL ACTIVITY; CONJUGATES SYNTHESIS; PLASMODIUM-FALCIPARUM; CARBOHYDRATE CHLOROQUINE; ORGANOMETALLIC ANALOG; BIOLOGICAL EVALUATION; DERIVATIVES SYNTHESIS; CYTOTOXIC ACTIVITY; ISATIN-FERROCENE; NEW-GENERATION;

D O I：

10.3390/molecules24193604

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial and is still an effective antimalarial. Many researchers have reported ferrocene compounds as potent compounds useful as anticancer and antimalarial agents when hybridized with other pharmaceutical scaffolds. This review will be focused on compounds with ferrocene moieties that exhibit either an anticancer or antimalarial activity.

引用

页数：27

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