Phosphonate MOFs Composite as Off-On Fluorescent Sensor for Detecting Purine Metabolite Uric Acid and Diagnosing Hyperuricuria

被引：98
作者：
Lian, Xiao [1 ]
Yan, Bing [1 ]
机构：
[1] Tongji Univ, Shanghai Key Lab Chem Assessment & Sustainabil, Sch Chem Sci & Engn, Siping Rd 1239, Shanghai 200092, Peoples R China
来源：
INORGANIC CHEMISTRY | 2017年 / 56卷 / 12期
基金：
中国国家自然科学基金;
关键词：
METAL-ORGANIC FRAMEWORK; LUMINESCENCE; ELECTRODE; CRYSTAL; HYBRID; SITES; IONS;
D O I：
10.1021/acs.inorgchem.6b03009
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The recent discovery of lanthanide organic frameworks (Ln-MOFs) offers the potential for biomarkers or metabolites sensing: This is another field that is closely connected with life science and medicine. In this work, a stable and luminescent phosphonate Ln-MOFs MIL-91(Al:Eu) and its derivatives composite Cu2+@MIL-91(Al:Eu) were synthesized. The rebound of luminescence of Cu2+@MIL-91(Al:Eu) that origin of Eu3 is observed in the presence of uric acid. This On-Off-On pattern is utilized for detecting uric acid, which is the final metabolite of purine. The composite reveals excellent selectivity and sensitivity for sensing uric acid. The detection of uric acid in real urine is also investigated. The effective detection of uric acid and tentative diagnosis of hyperuricuria on the basis of test paper is demonstrate.
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收藏
页码：6802 / 6808
页数：7
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