Clinical significance of tumor-stroma ratio in head and neck cancer: a systematic review and meta-analysis

被引：62

作者：

Almangush, Alhadi ^{[1
,2
,3
,4
,5
]}

Alabi, Rasheed Omobolaji ^{[6
]}

Troiano, Giuseppe ^{[7
]}

Coletta, Ricardo D. ^{[8
]}

Salo, Tuula ^{[3
,9
,10
,11
]}

Pirinen, Matti ^{[12
,13
,14
]}

Makitie, Antti A. ^{[2
,15
,16
,17
,18
]}

Leivo, Ilmo ^{[19
,20
]}

机构：

[1] Univ Helsinki, Dept Pathol, Haartmaninkatu 3,POB 21, Helsinki, Finland

[2] Univ Helsinki, Fac Med, Res Program Syst Oncol, Helsinki, Finland

[3] Univ Helsinki, Dept Oral & Maxillofacial Dis, Helsinki, Finland

[4] Univ Turku, Inst Biomed, Pathol, Turku, Finland

[5] Misurata Univ, Fac Dent, Misurata, Libya

[6] Univ Vaasa, Sch Technol & Innovat, Dept Ind Digitalizat, Vaasa, Finland

[7] Foggia Univ, Dept Clin & Expt Med, Foggia, Italy

[8] Univ Estadual Campinas, Sch Dent, Dept Oral Diag, Piracicaba, SP, Brazil

[9] Univ Helsinki, Dept Pathol, Helsinki, Finland

[10] Univ Oulu, Canc & Translat Med Res Unit, Med Res Ctr Oulu, Oulu, Finland

[11] Oulu Univ Hosp, Oulu, Finland

[12] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland

[13] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

[14] Univ Helsinki, Dept Math & Stat, Helsinki, Finland

[15] Univ Helsinki, Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[16] Helsinki Univ Hosp, Helsinki, Finland

[17] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, Stockholm, Sweden

[18] Karolinska Univ Hosp, Stockholm, Sweden

[19] Univ Turku, Inst Biomed Pathol, Turku, Finland

[20] Turku Univ Hosp, Turku, Finland

来源：

BMC CANCER | 2021年 / 21卷 / 01期

关键词：

Head and neck cancer; Tumor-stroma ratio; Tumor-stroma; Clinical relevance; Marker; Systematic review and meta-analysis; SQUAMOUS-CELL CARCINOMA; INDEPENDENT PREDICTOR; SURVIVAL;

D O I：

10.1186/s12885-021-08222-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background The clinical significance of tumor-stroma ratio (TSR) has been examined in many tumors. Here we systematically reviewed all studies that evaluated TSR in head and neck cancer. Methods Four databases (Scopus, Medline, PubMed and Web of Science) were searched using the term tumo(u)r-stroma ratio. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed. Results TSR was studied in nine studies of different subsites (including cohorts of nasopharyngeal, oral, laryngeal and pharyngeal carcinomas). In all studies, TSR was evaluated using hematoxylin and eosin staining. Classifying tumors based on TSR seems to allow for identification of high-risk cases. In oral cancer, specifically, our meta-analysis showed that TSR is significantly associated with both cancer-related mortality (HR 2.10, 95%CI 1.56-2.84) and disease-free survival (HR 1.84, 95%CI 1.38-2.46). Conclusions The assessment of TSR has a promising prognostic value and can be implemented with minimum efforts in routine head and neck pathology.

引用

页数：8

共 39 条

[1] Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer [J].