Towards the synthesis of amphidinolide B. An intramolecular Stille coupling approach

被引：34
作者：
Cid, MB [1 ]
Pattenden, G [1 ]
机构：
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 38期
关键词：
D O I：
10.1016/S0040-4039(00)01242-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthetic approach towards the cytotoxic polyene polyol macrolide amphidinolide B (1), based on elaboration of the C-1-C-13 carboxylic acid 4 and the C-14-C-25 alcohol 3 units, their esterification to the iodostannyl ester 2, and an intramolecular Stille sp(2)-sp(2) coupling reaction, is described. In spite of adequate precedent and model experiments, circumstances conspired and the aforementioned coupling reaction was not realised in this case. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：7373 / 7378
页数：6
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