Molecular and alternative methods for diagnosis of acute myeloid leukemia with mutated NPM1: flexibility may help

被引：25
作者：
Falini, Brunangelo [1 ]
Martelli, Maria Paola [1 ]
Pileri, Stefano A. [2 ,3 ]
Mecucci, Cristina [1 ]
机构：
[1] Univ Perugia, Inst Hematol, I-06100 Perugia, Italy
[2] Univ Bologna, Inst Hematol, Chair Hematopathol, Bologna, Italy
[3] Univ Bologna, Hematopathol Unit, Bologna, Italy
来源：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2010年 / 95卷 / 04期
关键词：
MINIMAL RESIDUAL DISEASE; ACUTE MYELOGENOUS LEUKEMIA; NUCLEOPHOSMIN GENE-MUTATIONS; CYTOPLASMIC NUCLEOPHOSMIN; QUANTITATIVE ASSESSMENT; CLINICAL-SIGNIFICANCE; NPMC(+) AML; CLASSIFICATION; EXPRESSION; ASSAY;
D O I：
10.3324/haematol.2009.017822
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：529 / 534
页数：6
相关论文
共 45 条
  • [1] Identification and functional characterization of a cytoplasmic nucleophosmin leukaemic mutant generated by a novel exon-11 NPM1 mutation
    Albiero, E.
    Madeo, D.
    Bolli, N.
    Giaretta, I.
    Di Bona, E.
    Martelli, M. F.
    Nicoletti, I.
    Rodeghiero, F.
    Falini, B.
    [J]. LEUKEMIA, 2007, 21 (05) : 1099 - 1103
  • [2] Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
    Alcalay, M
    Tiacci, E
    Bergomas, R
    Bigerna, B
    Venturini, E
    Minardi, SP
    Meani, N
    Diverio, D
    Bernard, L
    Tizzoni, L
    Volorio, S
    Luzi, L
    Colombo, E
    Lo Coco, F
    Mecucci, C
    Falini, B
    Pelicci, PG
    [J]. BLOOD, 2005, 106 (03) : 899 - 902
  • [3] Arber D A., 2008, WHO classification, P110
  • [4] Arber DA, 2001, AM J CLIN PATHOL, V115, P552
  • [5] Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation
    Bacher, Ulrike
    Badbaran, Anita
    Fehse, Boris
    Zabelina, Tatjana
    Zander, Axel Rolf
    Kroeger, Nicolaus
    [J]. EXPERIMENTAL HEMATOLOGY, 2009, 37 (01) : 135 - 142
  • [6] Minimal residual disease detection in acute myeloid leukemia by mutant nucleophosmin (NPM1):: Comparison with WT1 gene expression
    Barragan, Eva
    Pajuelo, Juan C.
    Ballester, Sandra
    Fuster, Oscar
    Cervera, Jose
    Moscardo, Federico
    Senent, Leonor
    Such, Esperanza
    Sanz, Miguel A.
    Bolufer, Pascual
    [J]. CLINICA CHIMICA ACTA, 2008, 395 (1-2) : 120 - 123
  • [7] Favorable Prognostic Impact of NPM1 Mutations in Older Patients With Cytogenetically Normal De Novo Acute Myeloid Leukemia and Associated Gene- and MicroRNA-Expression Signatures: A Cancer and Leukemia Group B Study
    Becker, Heiko
    Marcucci, Guido
    Maharry, Kati
    Radmacher, Michael D.
    Mrozek, Krzysztof
    Margeson, Dean
    Whitman, Susan P.
    Wu, Yue-Zhong
    Schwind, Sebastian
    Paschka, Peter
    Powell, Bayard L.
    Carter, Thomas H.
    Kolitz, Jonathan E.
    Wetzler, Meir
    Carroll, Andrew J.
    Baer, Maria R.
    Caligiuri, Michael A.
    Larson, Richard A.
    Bloomfield, Clara D.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (04) : 596 - 604
  • [8] The incidence and clinical significance of nucleophosmin mutations in childhood AML
    Brown, Patrick
    McIntyre, Emily
    Rau, Rachel
    Meshinchi, Soheil
    Lacayo, Norman
    Dahl, Gary
    Alonzo, Todd A.
    Chang, Myron
    Arceci, Robert J.
    Small, Donald
    [J]. BLOOD, 2007, 110 (03) : 979 - 985
  • [9] Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype
    Cazzaniga, G
    Dell'Oro, MG
    Mecucci, C
    Giarin, E
    Masetti, R
    Rossi, V
    Locatelli, F
    Martelli, MF
    Basso, G
    Pession, A
    Biondi, A
    Falini, B
    [J]. BLOOD, 2005, 106 (04) : 1419 - 1422
  • [10] Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations
    Chou, W-C
    Tang, J-L
    Wu, S-J
    Tsay, W.
    Yao, M.
    Huang, S-Y
    Huang, K-C
    Chen, C-Y
    Huang, C-F
    Tien, H-F
    [J]. LEUKEMIA, 2007, 21 (05) : 998 - 1004
12345