Nucleophilic Amination and Etherification of Aryl Alkyl Thioethers

被引：34

作者：

Wang, Xia ^{[1
]}

Tang, Yue ^{[1
]}

Long, Cheng-Yu ^{[2
]}

Dong, Wen-Ke ^{[1
]}

Li, Chenchen ^{[1
]}

Xu, Xinhua ^{[1
]}

Zhao, Wanxiang ^{[1
]}

Wang, Xue-Qiang ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Northwest Minzu Univ, Coll Chem Engn, Lanzhou 730030, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 16期

关键词：

NICKEL-CATALYZED AMINATION; CROSS-COUPLING REACTIONS; N BOND FORMATION; C-N; ARYLBORONIC ACIDS; REDUCTIVE ELIMINATION; MECHANISTIC INSIGHT; CARBON-SULFUR; LIGAND-FREE; COPPER;

D O I：

10.1021/acs.orglett.8b01758

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition-metal-free protocol capable of synthesizing diarylated aniline derivatives is reported. This method could be further employed to prepare aryl alkyl ethers. A wide range of thioethers, anilines, as well as alcohols were tolerated thanks to the mild reaction conditions. The strength of our method was demonstrated by performing a gram-scale reaction (20 mmol) followed by conversion of the nitrile group into synthetically useful aldehyde, ketone, and carboxylic acid.

引用

页码：4749 / 4753

页数：5

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