Evolution of B-type natriuretic peptide and N-terminal pro-brain natriuretic peptide during acute decompensated heart failure in a chronic heart failure patient with reduced ejection fraction treated with Sacubitril/Valsartan: a case report

被引：2

作者：

Tiepolo, Ambre ^{[1
,2
]}

Nougue, Helene ^{[1
,2
]}

Damoisel, Charles ^{[2
]}

Launay, Jean-Marie ^{[1
,3
,4
]}

Vodovar, Nicolas ^{[1
]}

Mebazaa, Alexandre ^{[1
,2
,5
]}

机构：

[1] Inserm UMR S 942, 41 Blvd Chapelle, F-75475 Paris 10, France

[2] St Louis & Lariboisiere Hosp, Dept Anaesthesiol & Intens Care, 2 Rue Ambroise Pare, F-75010 Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[4] Lariboisiere Hosp, Ctr Biol Resources BB 0033 00064, 2 Rue Ambroise Pare, F-75010 Paris, France

[5] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France

来源：

EUROPEAN HEART JOURNAL-CASE REPORTS | 2019年 / 3卷 / 03期

关键词：

BNP; NT-proBNP; Acute decompensated heart failure; Sacubitril/Valsartan; Case report;

D O I：

10.1093/ehjcr/ytz108

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background B-type natriuretic peptide (BNP) and the N-terminal proBNP (NT-proBNP) exhibit different evolution in chronic heart failure patients with reduced ejection fraction treated with Sacubitril/Valsartan; BNP increasing or remaining stable, while NT-proBNP decreases. However, how this difference translates upon acute decompensation is unknown. Case summary Herein, we described in a 78-year-old woman with chronic heart failure with reduced ejection fraction treated with Sacubitril/Valsartan who had acute decompensated heart failure (ADHF). BNP and NT-proBNP were markedly high during ADHF and showed parallel return to baseline level after clinical improvement. Discussion BNP and NT-proBNP retained similar value for the diagnosis of ADHF in patient treated with Sacubitril/Valsartan. These findings strongly suggest that either BNP or NT-proBNP can be used indifferently in this context, while their relative use is debated in chronic heart failure.

引用

页数：4

共 9 条

[1] Decompensated Heart Failure Is a Strong Independent Predictor of Functional Outcome After Ischemic Stroke [J].

Burkot, Jacek ;

Kopec, Grzegorz ;

Pera, Joanna ;

Slowik, Agnieszka ;

Dziedzic, Tomasz .

JOURNAL OF CARDIAC FAILURE, 2015, 21 (08) :642-646

[2] Cardiac troponins and N-terminal pro-brain natriuretic peptide in acute ischemic stroke do not relate to clinical prognosis [J].

Etgen, T ;

Baum, H ;

Sander, K ;

Sander, D .

STROKE, 2005, 36 (02) :270-275

[3] Unraveling N-Terminal Pro-B-Type Natriuretic Peptide: Another Piece to a Very Complex Puzzle in Heart Failure Patients [J].

Jaffe, Allan S. ;

Apple, Fred S. ;

Mebazaa, Alexandre ;

Vodovar, Nicolas .

CLINICAL CHEMISTRY, 2015, 61 (08) :1016-1018

[4] HYDROLYSIS OF HUMAN AND PIG BRAIN NATRIURETIC PEPTIDES, URODILATION, C-TYPE NATRIURETIC PEPTIDE AND SOME C-RECEPTOR LIGANDS BY ENDOPEPTIDASE-24.11 [J].

KENNY, AJ ;

BOURNE, A ;

INGRAM, J .

BIOCHEMICAL JOURNAL, 1993, 291 :83-88

[5] Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure: a mechanistic clinical study [J].

Nougue, Helene ;

Pezel, Theo ;

Picard, Francois ;

Sadoune, Malha ;

Arrigo, Mattia ;

Beauvais, Florence ;

Launay, Jean-Marie ;

Cohen-Solal, Alain ;

Vodovar, Nicolas ;

Logeart, Damien .

EUROPEAN JOURNAL OF HEART FAILURE, 2019, 21 (05) :598-605

[6]

Novartis, 2019, CTR DRUG EVALUATION

[7] Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure [J].

Packer, Milton ;

McMurray, John J. V. ;

Desai, Akshay S. ;

Gong, Jianjian ;

Lefkowitz, Martin P. ;

Rizkala, Adel R. ;

Rouleau, Jean L. ;

Shi, Victor C. ;

Solomon, Scott D. ;

Swedberg, Karl ;

Zile, Michael ;

Andersen, Karl ;

Arango, Juan Luis ;

Arnold, J. Malcolm ;

Belohlavek, Jan ;

Bohm, Michael ;

Boytsov, Sergey ;

Burgess, Lesley J. ;

Cabrera, Walter ;

Calvo, Carlos ;

Chen, Chen-Huan ;

Dukat, Andrej ;

Duarte, Yan Carlos ;

Erglis, Andrejs ;

Fu, Michael ;

Gomez, Efrain ;

Gonzalez-Medina, Angel ;

Hagege, Albert A. ;

Huang, Jun ;

Katova, Tzvetana ;

Kiatchoosakun, Songsak ;

Kim, Kee-Sik ;

Kozan, Oemer ;

Llamas, Edmundo Bayram ;

Martinez, Felipe ;

Merkely, Bela ;

Mendoza, Ivan ;

Mosterd, Arend ;

Negrusz-Kawecka, Marta ;

Peuhkurinen, Keijo ;

Ramires, Felix J. A. ;

Refsgaard, Jens ;

Rosenthal, Arvo ;

Senni, Michele ;

Sibulo, Antonio S., Jr. ;

Silva-Cardoso, Jose ;

Squire, Iain B. ;

Starling, Randall C. ;

Teerlink, John R. ;

Vanhaecke, Johan .

CIRCULATION, 2015, 131 (01) :54-61

[8] 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure [J].

Ponikowski, Piotr ;

Voors, Adriaan A. ;

Anker, Stefan D. ;

Bueno, Hector ;

Cleland, John G. F. ;

Coats, Andrew J. S. ;

Falk, Volkmar ;

Ramon Gonzalez-Juanatey, Jose ;

Harjola, Veli-Pekka ;

Jankowska, Ewa A. ;

Jessup, Mariell ;

Linde, Cecilia ;

Nihoyannopoulos, Petros ;

Parissis, John T. ;

Pieske, Burkert ;

Riley, Jillian P. ;

Rosano, Giuseppe M. C. ;

Ruilope, Luis M. ;

Ruschitzka, Frank ;

Rutten, Frans H. ;

van der Meer, Peter .

EUROPEAN HEART JOURNAL, 2016, 37 (27) :2129-U130

[9] The brain-heart connection [J].

Samuels, Martin A. .

CIRCULATION, 2007, 116 (01) :77-84

← 1 →