The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions

被引：40

作者：

Misquitta, Karen ^{[1
,10
]}

Dadar, Mahsa ^{[2
]}

Tarazi, Apameh ^{[3
,4
]}

Hussain, Mohammed W. ^{[3
,4
]}

Alatwi, Mohammed K. ^{[3
,4
]}

Ebraheem, Ahmed ^{[3
,4
]}

Multani, Namita ^{[1
,3
]}

Khodadadi, Mozhgan ^{[3
,4
]}

Goswami, Ruma ^{[3
,5
]}

Wennberg, Richard ^{[3
,4
]}

Tator, Charles ^{[3
,4
,6
,7
,10
]}

Green, Robin ^{[3
,8
,10
]}

Colella, Brenda ^{[3
,8
]}

Davis, Karen Deborah ^{[3
,5
,10
]}

Mikulis, David ^{[3
,9
,10
]}

Grinberg, Mark ^{[1
]}

Sato, Christine ^{[1
]}

Rogaeva, Ekaterina ^{[1
]}

Collins, D. Louis ^{[2
]}

Tartaglia, Maria Carmela ^{[1
,3
,4
,10
]}

机构：

[1] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Krembil Discovery Tower,60 Leonard Ave, Toronto, ON M5T 0S8, Canada

[2] McConnell Brain Imaging Ctr, Montreal Neurol Inst, 3801 Rue Univ, Montreal, PQ H3A 2B4, Canada

[3] Toronto Western Hosp, Canadian Concuss Ctr, 399 Bathurst St, Toronto, ON M5T 2S8, Canada

[4] Toronto Western Hosp, Krembil Neurosci Ctr, Div Neurol, 399 Bathurst St, Bathurst, ON M5T 2S8, Canada

[5] Toronto Western Hosp, Krembil Neurosci Ctr, Div Brain Imaging & Behav Syst Neurosci, 399 Bathurst St, Toronto, ON M5T 2S8, Canada

[6] Univ Toronto, Dept Surg, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada

[7] Toronto Western Hosp, Krembil Neurosci Ctr, Div Neurosurg, 399 Bathurst St, Bathurst, ON M5T 2S8, Canada

[8] Univ Hlth Network, Toronto Rehabil Inst, 550 Univ Ave, Toronto, ON M5G 2A2, Canada

[9] Toronto Western Hosp, Dept Med Imaging, 399 Bathurst St, Toronto, ON M5T 2S8, Canada

[10] Univ Toronto, Inst Med Sci, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada

来源：

NEUROIMAGE-CLINICAL | 2018年 / 19卷

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

Sport-related concussion; Mild traumatic brain injury; Deformation based morphometry; Aging; CHRONIC TRAUMATIC ENCEPHALOPATHY; DEFORMATION-BASED MORPHOMETRY; HEAD-INJURY; RECURRENT CONCUSSION; HIPPOCAMPAL VOLUME; LEAGUE PLAYER; MILD; MRI; SEGMENTATION; ASSOCIATION;

D O I：

10.1016/j.nicl.2018.05.014

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Multiple concussions, particularly in contact sports, have been associated with cognitive deficits, psychiatric impairment and neurodegenerative diseases like chronic traumatic encephalopathy. We used volumetric and deformation-based morphometric analyses to test the hypothesis that repeated concussions may be associated with smaller regional brain volumes, poorer cognitive performance and behavioural symptoms among former professional football players compared to healthy controls. This study included fifty-three retired Canadian Football League players, 25 age-and education-matched healthy controls, and controls from the Cambridge Centre for Aging and Neuroscience database for validation. Volumetric analyses revealed greater hippocampal atrophy than expected for age in former athletes with multiple concussions than controls and smaller left hippocampal volume was associated with poorer verbal memory performance in the former athletes. Deformation-based morphometry confirmed smaller bilateral hippocampal volume that was associated with poorer verbal memory performance in athletes. Repeated concussions may lead to greater regional atrophy than expected for age.

引用

页码：551 / 558

页数：8

共 56 条

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