Altered expression of protein p42IP4/centaurin-αI in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin

被引：22
作者：
Reiser, G
Bernstein, HG
机构：
[1] Univ Magdeburg, Inst Neurobiochem, D-39120 Magdeburg, Germany
[2] Klin Psychiat PSychotherapie Psychosomat Med, D-39120 Magdeburg, Germany
来源：
NEUROREPORT | 2004年 / 15卷 / 01期
关键词：
Alzheimer's disease; casein kinase I; human brain; nucleolin; p42(IPA)/centaurin-alpha I;
D O I：
10.1097/00001756-200401190-00028
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The protein p42(IP4) (centaurin-alphaI) is a brain-specific lnsP(4)/PtdIns(3) (PIP)-binding protein, whish is localized in neurons of the human brain. In Alzheimer's disease (AD) the intraneuronal expression of the protein was shown to be elevated. In addition, p42(IP4) immunostaining decorated neuritic plaques. Attempting to explain the putative role of the protein in AD, we have concentrated on its well-known interactions with casein kinase 1, which is known to be prominently involved in AD pathophysiology. Meanwhile, specific interaction of p42(IP4) with nucleolin, another player in AD pathology, has been revealed. Based on these data, we propose alternative concepts of how p42(IP4) might act in AD pathomechanisms.
引用
收藏
页码：147 / 148
页数：2
相关论文
共 21 条
[1]   Identification of rat brain p42IP4, a high-affinity inositol(1,3,4,5)tetrakisphosphate phosphatidylinositol(3,4,5)trisphosphate binding protein [J].
Aggensteiner, M ;
Stricker, R ;
Reiser, G .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1998, 1387 (1-2) :117-128
[2]   Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology [J].
Dranovsky, A ;
Vincent, I ;
Gregori, L ;
Schwarzman, A ;
Colflesh, D ;
Enghild, J ;
Strittmatter, W ;
Davies, P ;
Goldgaber, D .
NEUROBIOLOGY OF AGING, 2001, 22 (04) :517-528
[3]   Centaurin-α1 associates in vitro and in vivo with nucleolin [J].
Dubois, T ;
Zemlickova, E ;
Howell, S ;
Aitken, A .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (02) :502-508
[4]   Casein kinase I associates with members of the centaurin-α family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins [J].
Dubois, T ;
Kerai, P ;
Zemlickova, E ;
Howell, S ;
Jackson, TR ;
Venkateswarlu, K ;
Cullen, PJ ;
Theibert, AB ;
Larose, L ;
Roach, PJ ;
Aitken, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (22) :18757-18764
[5]   A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease [J].
Ghoshal, N ;
Smiley, JF ;
DeMaggio, AJ ;
Hoekstra, MF ;
Cochran, EJ ;
Binder, LI ;
Kuret, J .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (04) :1163-1172
[6]   Identification and cloning of centaurin-alpha - A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain [J].
HammondsOdie, LP ;
Jackson, TR ;
Profit, AA ;
Blader, IJ ;
Turck, CW ;
Prestwich, GD ;
Theibert, AB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18859-18868
[7]   Recombinant p42IP4, a brain-specific 42-kDa high-affinity Ins(1,3,4,5)P4 receptor protein, specifically interacts with lipid membranes containing Ptd-Ins(3,4,5)P3 [J].
Hanck, T ;
Stricker, R ;
Krishna, UM ;
Falck, JR ;
Chang, YT ;
Chung, SK ;
Reiser, G .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 261 (02) :577-584
[8]   Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases [J].
Husseman, JW ;
Nochlin, D ;
Vincent, I .
NEUROBIOLOGY OF AGING, 2000, 21 (06) :815-828
[9]   RELATION OF NEURONAL APP-751/APP-695 MESSENGER-RNA RATIO AND NEURITIC PLAQUE DENSITY IN ALZHEIMERS-DISEASE [J].
JOHNSON, SA ;
MCNEILL, T ;
CORDELL, B ;
FINCH, CE .
SCIENCE, 1990, 248 (4957) :854-857
[10]   Regulation of mRNA stability in the nervous system and beyond [J].
Malter, JS .
JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 66 (03) :311-316
123