Synergistic Catalysis: Enantioselective Addition of Alkylbenzoxazoles to Enals

被引：48
|
作者：
Meazza, Marta [1 ]
Ceban, Victor [1 ]
Pitak, Mateusz B. [1 ]
Coles, Simon J. [1 ]
Rios, Ramon [1 ]
机构：
[1] Univ Southampton, Fac Nat & Environm Sci, Southampton SO17 1BJ, Hants, England
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 51期
基金：
英国工程与自然科学研究理事会;
关键词：
alkyl azaarenes; iminium catalysis; Michael addition; palladium; synergistic catalysis; TRANSITION-METAL CATALYSIS; ALPHA-ALLYLATION; ORGANOCATALYSIS; ALKYLATION; ALDEHYDES; ALCOHOLS; STRATEGY;
D O I：
10.1002/chem.201404565
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel catalytic enantioselective methodology based on synergistic catalysis is reported. The strategy involves: 1) the metal-Lewis-acid activation of alkylazaarenes, and 2) the secondary-amine activation of enals. Consequently, highly functionalized chiral alkylazaarenes were obtained in good yields and with reasonable stereoselectivity.
引用
收藏
页码：16853 / 16857
页数：5
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