Synergistic Catalysis: Enantioselective Addition of Alkylbenzoxazoles to Enals

被引：48

作者：

Meazza, Marta ^{[1
]}

Ceban, Victor ^{[1
]}

Pitak, Mateusz B. ^{[1
]}

Coles, Simon J. ^{[1
]}

Rios, Ramon ^{[1
]}

机构：

[1] Univ Southampton, Fac Nat & Environm Sci, Southampton SO17 1BJ, Hants, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 51期

基金：

英国工程与自然科学研究理事会;

关键词：

alkyl azaarenes; iminium catalysis; Michael addition; palladium; synergistic catalysis; TRANSITION-METAL CATALYSIS; ALPHA-ALLYLATION; ORGANOCATALYSIS; ALKYLATION; ALDEHYDES; ALCOHOLS; STRATEGY;

D O I：

10.1002/chem.201404565

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel catalytic enantioselective methodology based on synergistic catalysis is reported. The strategy involves: 1) the metal-Lewis-acid activation of alkylazaarenes, and 2) the secondary-amine activation of enals. Consequently, highly functionalized chiral alkylazaarenes were obtained in good yields and with reasonable stereoselectivity.

引用

页码：16853 / 16857

页数：5

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