Cardiovascular Toxicity of Cyclooxygenase Inhibitors and Promising Natural Substitutes

被引:21
作者
Bahmani, Mahmoud [1 ]
Sarrafchi, Amir [2 ]
Shirzad, Hedayatollah [2 ]
Asgari, Sedigheh [3 ]
Rafieian-Kopaei, Mahmoud [2 ]
机构
[1] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran
[2] Shahrekord Univ Med Sci, Med Plants Res Ctr, Shahrekord, Iran
[3] Isfahan Univ Med Sci, Cardiovasc Res Inst, Cardiovasc Res Ctr, Esfahan, Iran
关键词
Cardiovascular; COX; NSAID; medicinal plants; oxidative stress; toxicity; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; THERAPEUTIC ARTHRITIS RESEARCH; CAMELLIA-SINENSIS EXTRACT; EVENT TRIAL TARGET; GREEN TEA; MEDICINAL-PLANTS; OXIDATIVE STRESS; COX-2; INHIBITORS; HYDROALCOHOLIC EXTRACT; LAVANDULA-OFFICINALIS;
D O I
10.2174/1381612822666161006144942
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are used for a wide variety of diseases including pain and inflammatory conditions such as osteoarthritis, rheumatoid arthritis, musculoskeletal disorders, and other comorbid complications. However, this group of drugs have undesirable effects such as peptic ulcer, bleeding and renal failure. Some of these side effects are associated with or caused by generation of oxidative stress. Following the withdrawal of a cyclo-oxygenase-2 (COX-2) inhibitor drug, rofecoxib (VIOXX (R)) due to cardiovascular complications, scientists suggested that natural COX-2 inhibitors might provide valuable alternatives to COX inhibitors. Although, most of medicinal plants reduce pain and inflammation in a similar manner to synthetic medications, however, they often have fewer side effects and are better tolerated. The present review other than focusing on cardiovascular and some other complications of NSAIDs, is trying to introduce the natural alternative remedies for these medications.
引用
收藏
页码:952 / 960
页数:9
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