Ten years of anti-vascular endothelial growth factor therapy

被引:810
作者
Ferrara, Napoleone [1 ]
Adamis, Anthony P. [2 ]
机构
[1] Univ Calif San Diego, La Jolla, CA 92093 USA
[2] Genentech Inc, San Francisco, CA 94080 USA
关键词
METASTATIC COLORECTAL-CANCER; VASCULAR-PERMEABILITY FACTOR; RENAL-CELL CARCINOMA; RANDOMIZED PHASE-III; RECEPTOR TYROSINE KINASES; ANTI-VEGF ANTIBODY; HUMANIZED MONOCLONAL-ANTIBODY; BEVACIZUMAB PLUS IRINOTECAN; FACTOR-INDUCED ANGIOGENESIS; MACULAR EDEMA SECONDARY;
D O I
10.1038/nrd.2015.17
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both normal and pathological angiogenesis, has revealed innovative therapeutic approaches in oncology and ophthalmology. The first VEGFA inhibitor, bevacizumab, was approved by the US Food and Drug Administration in 2004 for the first-line treatment of metastatic colorectal cancer, and the first VEGFA inhibitors in ophthalmology, pegaptanib and ranibizumab, were approved in 2004 and 2006, respectively. To mark this tenth anniversary of anti-VEGFA therapy, we discuss the discovery of VEGFA, the successes and challenges in the development of VEGFA inhibitors and the impact of these agents on the treatment of cancers and ophthalmic diseases.
引用
收藏
页码:385 / 403
页数:19
相关论文
共 278 条
[71]   Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability [J].
Eliceiri, BP ;
Paul, R ;
Schwartzberg, PL ;
Hood, JD ;
Leng, J ;
Cheresh, DA .
MOLECULAR CELL, 1999, 4 (06) :915-924
[72]   VEGF-targeted therapy: mechanisms of anti-tumour activity [J].
Ellis, Lee M. ;
Hicklin, Daniel J. .
NATURE REVIEWS CANCER, 2008, 8 (08) :579-591
[73]   Intravitreal Ranibizumab for Diabetic Macular Edema with Prompt versus Deferred Laser Treatment Three-Year Randomized Trial Results [J].
Elman, Michael J. ;
Qin, Haijing ;
Aiello, Lloyd Paul ;
Beck, Roy W. ;
Bressler, Neil M. ;
Ferris, Frederick L., III ;
Glassman, Adam R. ;
Maturi, Raj K. ;
Melia, Michele .
OPHTHALMOLOGY, 2012, 119 (11) :2312-2318
[74]   Expanded 2-Year Follow-up of Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema [J].
Elman, Michael J. ;
Bressler, Neil M. ;
Qin, Haijing ;
Beck, Roy W. ;
Ferris, Frederick L., III ;
Friedman, Scott M. ;
Glassman, Adam R. ;
Scott, Ingrid U. ;
Stockdale, Cynthia R. ;
Sun, Jennifer K. .
OPHTHALMOLOGY, 2011, 118 (04) :609-614
[75]   Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema [J].
Elman, Michael J. ;
Aiello, Lloyd Paul ;
Beck, Roy W. ;
Bressler, Neil M. ;
Bressler, Susan B. ;
Edwards, Allison R. ;
Ferris, Frederick L., III ;
Friedman, Scott M. ;
Glassman, Adam R. ;
Miller, Kellee M. ;
Scott, Ingrid U. ;
Stockdale, Cynthia R. ;
Sun, Jennifer K. .
OPHTHALMOLOGY, 2010, 117 (06) :1064-U65
[76]   Sorafenib in advanced clear-cell renal-cell carcinoma [J].
Escudier, Bernard ;
Eisen, Tim ;
Stadler, Walter M. ;
Szczylik, Cezary ;
Oudard, Stephane ;
Siebels, Michael ;
Negrier, Sylvie ;
Chevreau, Christine ;
Solska, Ewa ;
Desai, Apurva A. ;
Rolland, Frederic ;
Demkow, Tomasz ;
Hutson, Thomas E. ;
Gore, Martin ;
Freeman, Scott ;
Schwartz, Brian ;
Shan, Minghua ;
Simantov, Ronit ;
Bukowski, Ronald M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) :125-134
[77]   Phase III Trial of Bevacizumab Plus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma (AVOREN): Final Analysis of Overall Survival [J].
Escudier, Bernard ;
Bellmunt, Joaquim ;
Negrier, Sylvie ;
Bajetta, Emilio ;
Melichar, Bohuslav ;
Bracarda, Sergio ;
Ravaud, Alain ;
Golding, Sophie ;
Jethwa, Sangeeta ;
Sneller, Vesna .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (13) :2144-2150
[78]   Sorafenib for Treatment of Renal Cell Carcinoma: Final Efficacy and Safety Results of the Phase III Treatment Approaches in Renal Cancer Global Evaluation Trial [J].
Escudier, Bernard ;
Eisen, Tim ;
Stadler, Walter M. ;
Szczylik, Cezary ;
Oudard, Stephane ;
Staehler, Michael ;
Negrier, Sylvie ;
Chevreau, Christine ;
Desai, Apurva A. ;
Rolland, Frederic ;
Demkow, Tomasz ;
Hutson, Thomas E. ;
Gore, Martin ;
Anderson, Sibyl ;
Hofilena, Gloria ;
Shan, Minghua ;
Pena, Carol ;
Lathia, Chetan ;
Bukowski, Ronald M. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (20) :3312-3318
[79]   Randomized Phase II Trial of First-Line Treatment With Sorafenib Versus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma [J].
Escudier, Bernard ;
Szczylik, Cezary ;
Hutson, Thomas E. ;
Demkow, Tomasz ;
Staehler, Michael ;
Rolland, Frederic ;
Negrier, Sylvie ;
Laferriere, Nicole ;
Scheuring, Urban J. ;
Cella, David ;
Shah, Sonalee ;
Bukowski, Ronald M. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (08) :1280-1289
[80]   Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax [J].
Eswarappa, Sandeepa M. ;
Potdar, Alka A. ;
Koch, William J. ;
Fan, Yi ;
Vasu, Kommireddy ;
Lindner, Daniel ;
Wiiiard, Belinda ;
Graham, Linda M. ;
DiCorieto, Paul E. ;
Fox, Paul L. .
CELL, 2014, 157 (07) :1605-1618