Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis

被引：12

作者：

Inoue, Hirofumi ^{[1
]}

Matsushige, Takeshi ^{[1
]}

Ichiyama, Takashi ^{[2
]}

Okuno, Alato ^{[3
,4
]}

Takikawa, Osamu ^{[5
]}

Tomonaga, Shozo ^{[6
]}

Anlar, Banu ^{[7
]}

Yuksel, Deniz ^{[8
]}

Otsuka, Yasushi ^{[9
]}

Kohno, Fumitaka ^{[1
,2
]}

Hoshide, Madoka ^{[1
]}

Ohga, Shouichi ^{[10
]}

Hasegawa, Shunji ^{[1
]}

机构：

[1] Yamaguchi Univ, Dept Pediat, Grad Sch Med, 1-1-1 Minamikogushi, Ube, Yamaguchi 7558505, Japan

[2] Tsudumigaura Med Ctr Children Disabil, Div Pediat, Yamaguchi 7450801, Japan

[3] Tsukuba Int Univ, Fac Med & Hlth Sci, Tsukuba, Ibaraki 3000051, Japan

[4] Kobe Univ Hosp, Div Med Informat & Bioinformat, Kobe, Hyogo 6500017, Japan

[5] Japan Agcy Med Res & Dev, Dept Res Promot, Tokyo 1000004, Japan

[6] Kyoto Univ, Grad Sch Agr, Div Appl Biosci, Kyoto 6068501, Japan

[7] Hacettepe Univ, Fac Med, Dept Pediat Neurol, Ankara, Turkey

[8] Dr Sami Ulus Childrens Hosp, Dept Pediat Neurol, Ankara, Turkey

[9] Toki Gen Hosp, Dept Neurol, Gifu 5095193, Japan

[10] Kyushu Univ, Dept Pediat, Grad Sch Med Sci, Fukuoka, Fukuoka 8128582, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 339卷

关键词：

Kynurenine pathway; Quinolinic acid; Indoleamine-2; 3-dioxygenase; Subacute sclerosing panencephalitis; KYNURENINE PATHWAY METABOLISM; INDOLEAMINE 2,3-DIOXYGENASE; TRYPTOPHAN DEGRADATION; GENE POLYMORPHISM; ASSOCIATION; ACTIVATION; GAMMA;

D O I：

10.1016/j.jneuroim.2019.577088

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.

引用

页数：6

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