Clinical Presentations and Neurodevelopmental Outcomes of Perinatal Stroke in Preterm and Term Neonates: A Case Series

被引:14
作者
Lee, Hyun Ju [1 ,3 ]
Lim, Byung Chan [1 ]
Hwang, Hee [1 ]
Hong, Joon-Seok [2 ]
Kim, Ee-Kyung [3 ]
Kim, Han-Suk [3 ]
Kim, Beyong Il [1 ,3 ]
Choi, Jung-Hwan [3 ]
Choi, Chang Won [1 ,3 ]
机构
[1] Seoul Natl Univ, Dept Pediat, Bundang Hosp, Songnam 463707, South Korea
[2] Seoul Natl Univ, Dept Obstet & Gynecol, Bundang Hosp, Songnam 463707, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea
关键词
Perinatal Stroke; Newborn; Magnetic Resonance Imaging; MIDDLE CEREBRAL-ARTERY; ISCHEMIC-STROKE; SCHOOL-AGE; INFARCTION; INFANTS; CHILDREN; NEWBORN; RISK;
D O I
10.3346/jkms.2010.25.6.888
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Perinatal stroke in neonates can lead to disability in later life. However, its etiology and prognosis are poorly understood. The aim of this study was to describe clinical presentations and neurodevelopmental outcomes of our case series of perinatal stroke in Korea. Thirteen term and preterm neonates who were diagnosed with perinatal stroke in two university hospitals from March 2003 to March 2007 were enrolled. Seven term and 6 preterm neonates were diagnosed with perinatal stroke, based on the brain MRI findings. Perinatal stroke presented with seizure (4/13), perinatal distress (3/13) in term neonates, whereas stroke in preterm neonates did not present with noticeable clinical symptoms. Only one neonate had positive thrombophilic test (homozygous C677T polymorphism for MTHFR). Ten neonates had infarctions in the territory of the middle cerebral artery (MCA), and 3 neonates had borderzone infarctions between the anterior cerebral artery and MCA. Neurodevelopmental outcome was abnormal in 4 neonates. Infarction in MCA main branch or posterior limb of internal capsule showed an abnormal neurodevelopmental outcome. Our study is the first systematic study of perinatal stroke in Korea, and shows its clinical presentations and neurodevelopmental outcomes. The population-based study on incidence and prognosis of perinatal stroke in Korea is required in the future.
引用
收藏
页码:888 / 894
页数:7
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